Buy Fezam No. 60 capsules
  • Buy Fezam No. 60 capsules

Fezam No. 60 capsules

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Fezam №60 capsules - Instructions for use

Composition and release form
Capsules 1 caps
piracetam 400 mg
cinnarizine 25 mg
excipients: lactose; colloidal silicon dioxide; magnesium stearate  
capsule shell: titanium dioxide; gelatin  

in a blister strip package 10 pcs .; in a carton pack 6 packs.

Description of the dosage form

Capsules: solid, cylindrical, gelatin capsules of white color, №0.

Capsules content: crystalline powder, from white to pale cream color.

Characteristic

Combined drug.

pharmachologic effect

Pharmacological action - vasodilator, nootropic, antihypoxic.

Pharmacodynamics

Piracetam activates metabolic processes in the brain by increasing energy and protein metabolism, accelerating the utilization of glucose by cells and increasing their resistance to hypoxia; improves interneuronal transmission in the central nervous system, improves regional blood flow in the ischemic zone.

Cinnarizine is a selective blocker of slow calcium channels, inhibits the entry of calcium ions into cells and reduces their content in the plasmolemma depot, reduces the smooth muscle tone of arterioles, reduces their response to biogenic vasoconstrictor substances (epinephrine, norepinephrine, dopamine, angiotensin, vasopressin). It has a vasodilating effect (especially in relation to the vessels of the brain), enhancing the antihypoxic effect of piracetam and not having a significant effect on blood pressure. It shows moderate antihistamine activity, reduces the excitability of the vestibular apparatus, lowers the tone of the sympathetic nervous system. Increases the elasticity of erythrocyte membranes, their ability to deform, reduces blood viscosity.

Farmakokinetics
The drug is rapidly and completely absorbed in the digestive tract. Cmax Piracetam in plasma is created in 2–6 h, Cmax in liquor - after 2–8 hours. Bioavailability is 100%. Not bound to plasma proteins. It penetrates into all organs and tissues, passes the placental barrier. Selectively accumulates in the cerebral cortex, mainly in the frontal, parietal and occipital lobes, cerebellum and basal ganglia. Not metabolized. After 30 hours, more than 95% is excreted by the kidneys. Cmax Cinnarizine in plasma is created in 1–4 hours. It binds to plasma proteins by 91%.Actively and completely metabolized. T1/2 makes 4 h. 1/3 of metabolites is excreted with urine, 2/3 - with feces.

Indications of the drug Fezam

Insufficiency of cerebral blood circulation (atherosclerosis of cerebral vessels, recovery period of ischemic and hemorrhagic strokes, head injuries, encephalopathy of various genesis).

Intoxication.
Other diseases of the central nervous system, accompanied by a decrease in intellectual-mnestic functions (impaired memory, attention, mood).

Psychoorganic syndrome with a predominance of signs of asthenia and adynamia, asthenic syndrome.

Labyrinthopathy, Meniere's syndrome.
The backlog of intellectual development in children.
Prevention of migraine and kinetoz.

Contraindications

Individual intolerance, severe violations of the liver and / or kidneys, parkinsonism, pregnancy, breastfeeding period, children under 5 years of age.

With care - Parkinson's disease.

Use during pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Side effects

Dyspepsia, headache, sleep disorders. Rarely - allergic reactions in the form of a skin rash.

Interaction

With simultaneous admission, it is possible to increase the sedative effect of the agents that inhibit the activity of the central nervous system, as well as alcohol, nootropic and antihypertensive drugs. Vasodilators enhance the effect of the drug. Improves tolerability of antipsychotic drugs and tricyclic antidepressants.

Dosage and administration

Inside The usual dose for adults is 1–2 caps. 3 times a day for 1-3 months, depending on the severity of the disease. The course of treatment is 2-3 times a year. Children (over 5 years old) - 1–2 caps. 1-2 times a day. Do not use for more than 3 months.

Precautionary measures

The drug should be prescribed with caution to persons with diseases of the liver and / or kidneys. In cases of mild and moderate renal failure (especially if creatinine Cl is <60 ml / min), reduce the therapeutic dose or increase the intervals between doses. In persons with impaired liver function, it is necessary to control the content of liver enzymes. Alcohol should be avoided during treatment. The drug should be carefully prescribed with increased intraocular pressure, as well as in Parkinson's disease.During treatment, care should be taken when driving and working with machines and equipment.

special instructions

Cinnarizine can cause a positive reaction during the doping test in athletes.

It is possible to change the results of determination of radioactive iodine (dyes in the capsule shell contain iodine).

Storage conditions of the drug Fezam

In a dry, dark place at a temperature of no higher than 25 &№176; C.
Keep out of the reach of children.

The shelf life of the drug Fezam

3 years.
Do not use after the expiration date printed on the package.


It is a drug. Consultation with a doctor is required.
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