Teturam 150mg №50 pills
Drug for the treatment of alcohol dependence
Pharmaco-therapeutic group:Alcohol Cure
IndicationsFor oral administration: prevention of relapse during treatment of chronic alcoholism.
For implantation: treatment of chronic alcoholism, as a detoxification agent for chronic nickel poisoning.
Dosing regimenWhen ingestion dose is 125-500 mg / day, the treatment regimen is determined individually.
When implanted into the subcutaneous fat using a special technique, 800 mg is administered.
Side effectOn the part of the digestive system: metallic taste in the mouth; rarely, hepatitis.
From the side of the central nervous system: polyneuritis of the lower extremities, neuropsychiatric disorders, memory loss, disorientation, headache.
Allergic reactions: skin rash, itching.
Reactions due to the association of disulfiram-ethanol: collapse, cardiac arrhythmias, strokes, myocardial infarction, brain swelling.
ContraindicationsSevere cardiovascular diseases, severe liver failure, diabetes, epilepsy, neuropsychiatric diseases; simultaneous administration of phenytoin, isoniazid, metronidazole, simultaneous consumption of beverages containing alcohol or medication containing ethanol, as well as their consumption within 24 hours after administration of disulfiram; pregnancy, lactation; hypersensitivity to disulfiram.
Use during pregnancy and lactation
Contraindicated for use during pregnancy and lactation.
Pregnancy should be excluded before implantation. Against the background of the action of disulfiram, it is necessary to use reliable contraception.
Application for violations of the liver
Contraindicated in severe liver failure. Use with caution in patients with liver disease.
Application for violations of kidney function
Use with caution in patients with renal insufficiency.
special instructionsUse with caution in patients with renal insufficiency, diseases of the liver, respiratory system.
Drug interactionWhen applied simultaneously with anticoagulants coumarin derivatives (including with warfarin) increases the anticoagulant effect, increases the risk of bleeding.
Disulfiram inhibits liver enzymes, therefore, with simultaneous use of drugs metabolized in the liver, a violation of their metabolism is possible.
With the simultaneous use of disulfiram with tricyclic antidepressants, phenothiazine derivatives, MAO inhibitors, there is a risk of serious adverse reactions associated with drug interactions.
A case of the development of mania in a patient taking disulfiram and buspirone is described.
With simultaneous use decreases the clearance of desipramine and imipramine from the body.
With simultaneous use with amitriptyline, it is possible to enhance the therapeutic effect of disulfiram, but it is also possible to increase the toxic effect of amitriptyline on the central nervous system.
With simultaneous use increases in plasma concentration of diazepam and chlordiazepoxide, in some cases accompanied by dizziness. Under the influence of diazepam, it is possible to reduce the intensity of the disulfiram-alcohol reaction. Described case of increasing the toxicity of temazepam.
With simultaneous use with isoniazid described cases of dizziness, depression; caffeine - reduced excretion of caffeine from the body; with metronidazole - acute psychosis, confusion; with omeprazole - described a case of developmental disorders of consciousness and catatonia.
When applied simultaneously with perphenazine, the development of psychotic symptoms cannot be excluded.
With the simultaneous use of disulfiram inhibits metabolism and elimination of rifampicin.
With simultaneous use with phenazone increases T1/2 phenazone; with phenytoin - the effects of phenytoin are enhanced due to an increase in its concentration in the blood plasma, toxic reactions develop.
With simultaneous use with chlorzoxazone, the concentration of chlorzoxazone in the blood plasma increases; with chlorpromazine - possible increase in arterial hypotension.
It is a pharmaceutical drug. Use only as directed by your doctor.
Mode of application