Feksadin 120mg №10 pills

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Feksadin 120mg №10 pills

pharmachologic effect

Histamine H1 receptor blocker. Fexofenadine is a pharmacologically active metabolite of terfenadine. Does not have a sedative effect.
The antihistamine effect appears after 1 h, reaching a maximum after 6 h and lasts for 24 h. After 28 days of administration, no addiction was observed.
It was found that when administered orally in the dose range from 10 mg to 130 mg, the efficacy of fexofenadine is dose-dependent.

Pharmacokinetics

After ingestion, it is rapidly absorbed from the gastrointestinal tract, Cmax is determined after 1-3 hours. The average value of Cmax after administration of 180 mg is approximately 494 ng / ml, and after administration of 120 mg - 427 ng / ml. Plasma protein binding is 60-70%. T1 / 2 after repeated administration - 11-15 hours. It is excreted in breast milk. 5% of the dose undergoes partial extrahepatic metabolism. Predominantly excreted in bile (80%), 10% excreted by the kidneys unchanged.

Dosage

For adults and children over 12 years of age, the daily dose is 120-180 mg (1 time / day).

Drug interaction

Fexofenadine is not biotransformed in the liver and therefore does not interact with other drugs undergoing hepatic metabolism.
It was shown that with simultaneous administration of fexofenadine with erythromycin or ketoconazole, the concentration of fexofenadine in plasma increases by a factor of 2-3, which is apparently due to an increase in absorption from the gastrointestinal tract and a decrease in either bile or gastrointestinal secretion. No changes in the QT interval were observed.
When taking aluminum or magnesium-containing antacids 15 minutes before taking fexofenadine, a decrease in its bioavailability was observed, most likely due to binding in the gastrointestinal tract. The recommended time interval between taking fexofenadine and antacids containing aluminum or magnesium hydroxide is 2 hours.
Does not interact with omeprazole, with drugs metabolized in the liver.

Pregnancy and lactation

Fexofenadine is contraindicated for use during pregnancy and lactation (breastfeeding).
Fexofenadine passes into breast milk. If necessary, use fexofenadine during lactation should decide on the termination of breastfeeding.

Side effects

Possible: headache, drowsiness, dizziness, fatigue, nausea, lethargy, fatigue.

Indications

Elimination of symptoms associated with seasonal allergic rhinitis, symptomatic treatment of chronic urticaria.

Contraindications

Pregnancy, lactation period, children under 6 years of age, hypersensitivity to fexofenadine.

special instructions

Use with caution in elderly patients, in patients with renal or hepatic insufficiency.
The efficacy and safety of fexofenadine in children under 6 years of age have not been studied.

Influence on ability to drive motor transport and control mechanisms

Based on the pharmacodynamic profile and known side effects, it can be assumed that the effect of fexofenadine on the ability to drive motor vehicles and activities requiring increased concentration of attention is unlikely. When conducting objective studies it was shown that fexofenadine does not have a significant effect on the functions of the central nervous system. However, it is recommended to check the individual reaction before starting to drive a motor vehicle or to other potentially dangerous activities.

When kidney damage

Use with caution in patients with renal insufficiency.

With abnormal liver function

Use with caution in patients with liver failure.

Use in old age

Use with caution in elderly patients.

Use in childhood

The use of the drug in children under 6 years is not recommended.

It is a pharmaceutical drug. Use only as directed by your doctor.