Fenkarol 25mg №20 pills / Olainfarm /

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Fenkarol 25mg №20 pills / Olainfarm /

pharmachologic effect 
Histamine H1 receptor blocker. Prevents the development and facilitates the course of allergic reactions. It has antiallergic, antiexudative and antipruritic effect, preventing the development of allergic inflammation in the tissue. It weakens the effect of histamine, reduces its effect on vascular permeability (reducing permeability, has a decongestant effect), reduces its bronchospastic effect and spasmogenic effect on the smooth muscle of the intestine, weakens the hypotensive effect of histamine. Hifenadine reduces the content of histamine in tissues (associated with the ability to activate diaminooxidase - an enzyme that inactivates histamine). In the course of treatment, the antihistamine effect of Hifenadine is not reduced. It has a moderate anti-serotonin effect, exhibits weak m-anticholinergic activity. It has no inhibitory effect on the central nervous system.

Pharmacokinetics 
Suction and distribution
Hifenadine is rapidly absorbed from the gastrointestinal tract, absorption is 45%, and after 30 minutes is detected in the tissues of the body. Cmax in blood plasma is achieved after 1 h. It has low lipophilicity, poorly penetrates the blood-brain barrier. The highest concentration of the active substance is found in the liver, slightly lower in the lungs and kidneys, the lowest in the brain (less than 0.05%, which explains the absence of a depressant effect on the central nervous system).
Metabolism and excretion
Hifenadine is metabolized in the liver.
Metabolites are excreted by the kidneys and intestines. Unabsorbed part of the drug is excreted through the intestine.

Dosage 
The drug is taken orally after a meal.
The dosing regimen is the same for all indications for use. The dosage of Hifenadine may be influenced by the severity of the allergic reaction, the individual sensitivity of the patient, as well as the severity of possible side effects.
Adults appoint 25-50 mg 3-4 times / day. The maximum daily dose is 200 mg. The course of treatment is 10-20 days. If necessary, repeat the treatment.
Children aged 3 to 7 years - 10 mg 2 times / day; between the ages of 7 and 12 years, 10-15 mg 2-3 times / day; over 12 years old - 25 mg 2-3 times / day. The course of treatment is 10-15 days.

Overdose 
Symptoms: dry mucous membranes, headache, vomiting, abdominal pain and other symptoms of dyspepsia.
Treatment: gastric lavage, taking activated charcoal, conducting symptomatic therapy.
In case of overdose, the patient should consult a doctor.

Drug interaction 
Possessing weak m-holinoblokiruyuschimi properties, the drug can reduce the motility of the gastrointestinal tract, which increases the absorption of slowly absorbed drugs (for example, indirect anticoagulants - coumarins).

Pregnancy and lactation 
Not recommended for use during pregnancy. If necessary, use during pregnancy should carefully weigh the ratio of the estimated benefits to the mother and the risk to the fetus.
If necessary, treatment with the drug breastfeeding should be stopped.

Side effects 
On the part of the digestive system: dryness of the oral mucosa, nausea, vomiting.
CNS: drowsiness, headache.
Other: allergic reactions.

Terms and conditions of storage 
The drug should be kept out of the reach of children, dry, protected from light. Shelf life - 4 years.

Indications 
- pollinosis;
- acute and chronic urticaria;
- angioedema;
- allergic rhinitis;
- dermatosis (including eczema, psoriasis, atopic dermatitis, pruritus).

Contraindications 
- pregnancy;
- lactation period (breastfeeding);
- children's age up to 3 years (for this dosage form);
- deficiency of sucrase / isomaltase, fructose intolerance, glucose / galactose malabsorption, since the product contains sucrose;
- hypersensitivity to the drug.

special instructions 
Precautions should be prescribed the drug for diseases of the digestive tract, liver and kidneys.
The absence of a pronounced m-anticholinergic effect allows the drug to be prescribed to patients for whom antihistamines with m-anticholinergic activity are contraindicated.

Influence on ability to drive motor transport and control mechanisms
Persons whose profession requires an increased concentration of attention and quickness of psychomotor reactions should be predetermined (by short-term administration) if the drug does not have a sedative effect.

When kidney damage 
Precautions should be prescribed the drug for kidney disease.

With abnormal liver function 
Precautions should be prescribed the drug for liver disease.

Use in childhood 
The drug is prescribed to children aged 3 years and older.

Pharmacy sales terms 
The drug is approved for use as a means of OTC.

It is a drug. Consultation with a doctor is required.