Tavegil 1mg №20 pills

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Tavegil 1mg №20 pills

Latin name 
TAVEGYL

Release form 
Pills.

Composition 
1 tablet contains:
Active substances: clemastine 1 mg, equivalent to 1.34 mg of clemastine hydro-fumarate.
Excipients: lactose monohydrate, povidone (polyvinylpyrrolidone), corn starch, magnesium stearate, talc.

pharmachologic effect 
Pharmacodynamics
H 1 - histamine blocker - a derivative of ethanolamine.
Act
Antipruritic, anti-allergic. Reduces vascular permeability. It has a sedative and M-anticholinergic effect. Does not possess hypnotic activity. Prevents the development of vasodilation and smooth muscle contractions induced by histamine. Reduces capillary permeability. Inhibits exudation and the formation of edema, reduces itching.
Antihistamine activity of the drug reaches a maximum after 5-7 hours, persists for 10-12 hours, and in some cases - up to 24 hours.
Pharmacokinetics
After ingestion, clemastine is almost completely absorbed from the gastrointestinal tract. The maximum plasma concentration is reached in 2-4 hours. Communication with plasma proteins is 95%. Removal from plasma in two phases, the corresponding elimination half-life is 3.6 &№177; 0.9 hours and 37 &№177; 16 hours.
Clemastine undergoes significant metabolism in the liver. Metabolites are mainly (45-65%) excreted through the kidneys in the urine; unchanged active substance is found in urine only in trace amounts.
During lactation, a small amount of clemastin can pass into breast milk.

Indications 
Hay fever (allergic rhinoconjunctivitis);
urticaria of different origin;
itching, itchy dermatosis;
acute and chronic eczema, contact dermatitis;
drug allergy;
insect bites and stings.

Contraindications 
Hypersensitivity;
taking MAO inhibitors;
diseases of the lower respiratory tract (including bronchial asthma);
Tavegil should not be used in women during lactation;
Tavegil in pill form should not be used in children under 6 years of age.
With care: in patients with stenosing gastric ulcer; pyloroduodenal obstruction; with bladder neck obstruction; prostatic hypertrophy accompanied by urinary retention; with increased intraocular pressure; hyperthyroidism; diseases of the cardiovascular system, including arterial hypertension.

Use during pregnancy and lactation 
During pregnancy, Tavegil is used only if the expected benefit to the mother outweighs the potential risk to the fetus.

Dosage and administration 
Adults and children over 12 years of age: 1 tablet (1 mg) is prescribed in the morning and evening. In cases difficult to treat, the daily dose can be up to 6 pills (6 mg). pills should be taken before meals with water.
Children aged 6-12 years: appoint 1 / 2-1 tablet before breakfast and at night.

Side effects 
From the central nervous system: possible fatigue, drowsiness, headache, dizziness, tremor, sedation, weakness, fatigue, lethargy, incoordination; in rare cases, especially in children, a stimulating effect on the central nervous system is noted: anxiety, irritability, agitation, nervousness, insomnia, hysteria, euphoria, convulsions, paresthesia, neuritis.
On the part of the gastrointestinal tract: dyspepsia, nausea, epigastric pain, constipation, vomiting; rarely, dry mouth, occasional loss of appetite and diarrhea.
From the senses: a violation of the clarity of visual perception, diplopia, sharp labyrinthitis, tinnitus.
From the urinary system: very rarely - frequent or difficult urination.
On the part of the respiratory system: rarely - thickening of bronchial secretions and difficulty in sputum discharge, pressure sensation in the chest and difficulty breathing, nasal congestion.
Since the cardiovascular system: rarely - lowering blood pressure (more often in elderly patients), heartbeat, extrasystole.
From the side of blood-forming organs: hemolytic anemia, thrombocytopenia, agranulocytosis.
Allergic reactions: very rarely - urticaria, skin rash, photosensitivity, anaphylactic shock.

special instructions 
To prevent distortion of the results of skin scarification tests for allergens, the drug should be canceled 72 hours before the allergic testing.
Influence on the ability to drive vehicles and other mechanisms that require high concentration of attention
Patients taking Tavegil, it is recommended to refrain from driving vehicles, working with mechanisms, as well as from other activities that require high concentration of attention and speed of psychomotor reactions.

Drug interaction 
Tavegil enhances the action of drugs that depress the central nervous system (hypnotics, sedatives, anxiolytics), M-holinoblokatorov, as well as alcohol.
Not compatible with the simultaneous use of MAO inhibitors.

Overdose 
Symptoms: An overdose of antihistamines can lead to both depressing and stimulating effects on the central nervous system. CNS stimulation is more common in children. Phenomena of anticholinergic action may also develop: dry mouth, fixed pupil dilation, rush of blood to the upper half of the body, disorders of the gastrointestinal tract (nausea, epigastric pain, vomiting).
Treatment: if the patient does not vomit spontaneously, then it should be triggered (only if the patient’s mind is preserved). If 3 hours or a little more has passed since the drug was taken, it is necessary to wash the stomach with a 0.9% solution of sodium chloride and activated carbon. You can also assign a saline laxative. Symptomatic therapy is also indicated.

Storage conditions 
Store at a temperature not higher than 30 &№176; C.
Keep out of reach of children.

Shelf life 
5 years.


It is a drug. Consultation with a doctor is required.