Novocaine solution 0.5% 5 ml № 10 amp.

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Novocaine solution 0.5% 5 ml № 10 amp.

Special features
Interaction
Strengthens the inhibitory effect on the central nervous system of other drugs. Anticoagulants (ardeparin sodium, dalteparin sodium, danaparoid sodium, enoxaparin sodium, heparin, warfarin) increase the risk of bleeding. With simultaneous use of local anesthetic drugs for spinal and epidural anesthesia with guanadrel, guanethidine, mecamylamine, trimetaphan cilcilate increases the risk of a sharp decrease in blood pressure and bradycardia.

Pharmaceutical action

Local anesthetic with moderate anesthetic activity and a wide breadth of therapeutic action.
Contraindications

Hypersensitivity to local anesthetic esters.

special instructions
The main reason for the development of undesirable reactions when using procaine is a high plasma concentration, which can be observed due to overdose, rapid systemic absorption, unintentional intravascular administration, or slow metabolic degradation. In this regard, during anesthesia, it is necessary to monitor the vital functions of the body (heart rate, blood pressure, respiratory rate).

Side effects
 From the central and peripheral nervous system: headache, dizziness, drowsiness, weakness, tremor, visual and auditory disturbances, nystagmus.

From the CCC: increase or decrease in blood pressure, peripheral vasodilation, collapse, bradycardia, arrhythmia, chest pain. From the side of blood: methemoglobinemia.
Other: hypothermia; during anesthesia in dentistry: insensitivity and paresthesia of the lips and tongue, trismism.
Allergic reactions: urticaria, pruritus, erythema, angioedema (including laryngeal edema), anaphylactic shock.


It is a pharmaceutical drug. Use only as directed by your doctor.

Mode of application

The dose and concentration of the procaine solution depends on the nature of the surgery, the method of use, the condition and age of the patient.
For infiltration anesthesia, 0.25-0.5% solutions are used;
for anesthesia according to the Vishnevsky method (tight creeping infiltration) - 0.125-0.25% solutions;
for conduction anesthesia - 1-2% solutions (up to 25 ml);
for epidural - 2% solution (20-25 ml);
for spinal - 5% solution (2-3 ml);
for terminal anesthesia (in otorhinolaryngology) - 10-20% solution.
To reduce the absorption and elongation of action under local anesthesia, a 0.1% solution of epinephrine hydrochloride is additionally injected - 1 cap in 2-5-10 ml of procaine solution.
Higher doses for infiltration anesthesia for adults: the first single dose at the beginning of the operation is no more than 1 g of a 0.25% solution (500 ml) and 0.75 g of a 0.5% solution (150 ml). The maximum dose for use in children up to 15 mg / kg.