Allopurinol pills 300mg 30 pcs.
Treatment and prevention of gout and hyperuricemia of various genesis (including in combination with nephrolithiasis, renal failure, urate nephropathy). Recurrent mixed oxalate-calcium kidney stones in the presence of hyperuricuria. Increased urate formation due to enzyme disorders. Prevention of acute nephropathy with cytostatic and radiation therapy of tumors and leukemias, as well as with complete therapeutic fasting.
ContraindicationsSevere disorders of the liver and / or kidneys, pregnancy, lactation, hypersensitivity to allopurinol.
Pharmacological propertiesA means of violating the synthesis of uric acid. It is a structural analogue of hypoxanthine. Inhibits the enzyme xanthine oxidase, which is involved in the conversion of hypoxanthin to xanthine and xanthine to uric acid. This is due to a decrease in the concentration of uric acid and its salts in body fluids and urine, which helps dissolve existing urate deposits and prevent their formation in the tissues and kidneys. Allopurinol increases the excretion of hypoxanthin and xanthine with urine.
PharmacokineticsAfter ingestion, almost completely (90%) is absorbed from the gastrointestinal tract. It is metabolized with the formation of alloxanthin, which retains the ability to inhibit xanthine oxidase for quite a long time. Cmax of allopurinol in the blood plasma is reached on average 1.5 h, of alloxanthin 4.5 h after a single dose.
Allopurinol T1 / 2 is 1-2 hours, alloxanthin - about 15 hours. About 20% of the dose taken is excreted through the intestines, the rest - by the kidneys.
Pregnancy and lactation periodContraindicated for use in pregnancy and lactation (breastfeeding).
Side effectsSince the cardiovascular system: in rare cases - arterial hypertension, bradycardia.
On the part of the digestive system: dyspeptic phenomena are possible (including nausea, vomiting), diarrhea, a transient increase in the activity of transaminases in the blood serum; rarely, hepatitis; in rare cases, stomatitis, abnormal liver function (transient increase in transaminase and alkaline phase activity), steatorrhea.
On the part of the central nervous system and peripheral nervous system: in isolated cases - weakness, fatigue, headache, dizziness, ataxia, drowsiness, depression, coma, paresis, paresthesia, convulsions, neuropathy, visual disturbances, cataracts, changes in the optic papilla, disorders of taste sensations.
From the hematopoietic system: in some cases - thrombocytopenia, agranulocytosis and aplastic anemia, leukopenia (most likely in patients with impaired renal function).
On the part of the urinary system: rarely - interstitial nephritis; in isolated cases - edema, uremia, hematuria.
On the part of the endocrine system: in rare cases - infertility, impotence, gynecomastia, diabetes mellitus.
On the part of metabolism: in isolated cases - hyperlipidemia.
Allergic reactions: skin rash, hyperemia, itching; in some cases - angioimmunoblastic lymphadenopathy, arthralgia, fever, eosinophilia, fever, Stevens-Johnson syndrome, Lyell's syndrome.
Dermatological reactions: in isolated cases - furunculosis, alopecia, hair discoloration.
Interaction with other drugsWith the simultaneous use of allopurinol enhances the effect of coumarin anticoagulants, adenine arabinoside, as well as hypoglycemic drugs (especially for violations of renal function).
Uricosuric drugs and salicylates in high doses reduce the activity of allopurinol.
With the simultaneous use of allopurinol and cytostatics myelotoxic effect is more often manifested than with separate use.
With simultaneous use of allopurinol and azathioprine or mercaptopurine, cumulation of the latter is observed in the body, since due to the inhibition by allopurinol of the activity of xanthine oxidase, which is necessary for the biotransformation of drugs, their metabolism and elimination slows down.
special instructionsAllopurinol should be used with caution in cases of impaired liver and / or kidney function (in both cases, a dose reduction is needed) and thyroid hypofunction. In the initial period of the course of therapy with allopurinol, systematic evaluation of indicators of liver function is necessary.
During the period of treatment with allopurinol, the daily amount of fluid consumed must be at least 2 liters (under the control of diuresis).
At the beginning of the course of treatment for gout, an exacerbation of the disease may occur. For prevention, you can use NSAIDs or colchicine (0.5 mg 3). It should be borne in mind that with adequate therapy with allopurinol, the dissolution of large urate stones in the renal pelvis and their subsequent entry into the ureter may occur.
Asymptomatic hyperuricemia is not an indication for the use of allopurinol.
In children, it is used only for malignant neoplasms (especially leukemia), as well as for some enzyme disorders (Lesch-Nihena syndrome).
To correct hyperuricemia in patients with neoplastic diseases, allopurinol is recommended to be used before starting treatment with cytostatics. In such cases, the minimum effective dose should be applied. In addition, in order to reduce the risk of xanthine deposits in the urinary tract, it is necessary to take measures to maintain optimal diuresis and alkalinization of urine. With simultaneous use of allopurinol and cytostatics, more frequent monitoring of the peripheral blood pattern is necessary.
In the period of taking allopurinol alcohol is not allowed.
Influence on ability to drive motor transport and control mechanismsUse with caution in patients whose activities require a high concentration of attention and quick psychomotor reactions.
It is a pharmaceutical drug. Use only as directed by your doctor.