Allopurinol pills egis 300mg 30 pcs.

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Allopurinol pills egis 300mg 30 pcs.

Pharmaceutical action

A means of violating the synthesis of uric acid. It is a structural analogue of hypoxanthine. Inhibits the enzyme xanthine oxidase, which is involved in the conversion of hypoxanthin to xanthine and xanthine to uric acid. This is due to a decrease in the concentration of uric acid and its salts in body fluids and urine, which helps dissolve existing urate deposits and prevent their formation in the tissues and kidneys. Allopurinol increases the excretion of hypoxanthin and xanthine with urine.

Contraindications

Severe liver and / or kidney function, pregnancy, lactation. Hypersensitivity to allopurinol.

special instructions

Side effects:
Since the cardiovascular system: in isolated cases - arterial hypertension, bradycardia.
From the digestive system: possible dyspeptic phenomena (including nausea, vomiting), diarrhea, transient increase in serum transaminases rarely - hepatitis in isolated cases - stomatitis, abnormal liver function (transient increase in transaminase and alkaline phosphatase), steatorrhea.
From the side of the central nervous system: in isolated cases - weakness, fatigue, headache, dizziness, ataxia, drowsiness, depression, coma, paresis, paresthesia, convulsions, neuropathy, visual disturbances, cataracts, changes in the optic papilla, disorders of taste.
From the hemopoietic system: in some cases - thrombocytopenia, agranulocytosis and aplastic anemia, leukopenia, which are most likely in patients with impaired renal function.
From the urinary system: rarely - interstitial nephritis in isolated cases - edema, uremia, hematuria.
On the part of the endocrine system: in rare cases - infertility, impotence, gynecomastia, diabetes.
Metabolism: in isolated cases - hyperlipidemia.
Allergic reactions: possible skin rash, hyperemia, itching in some cases - angioimmunoblastic lymphadenopathy, arthralgia, lymphadenopathy, fever, eosinophilia, fever.
Dermatological reactions: in rare cases - furunculosis, alopecia, hair bleaching.
Pregnancy:
Contraindicated for use during pregnancy and lactation.
Interaction:
With the simultaneous use of allopurinol enhances the effect of coumarin anticoagulants, adenine arabinoside, as well as hypoglycemic drugs (especially for violations of renal function). Uricosuric drugs and salicylates in high doses reduce the activity of allopurinol. With the simultaneous use of allopurinol and cytostatics myelotoxic effect is more often manifested than with separate use. With simultaneous use of allopurinol and azathioprine or mercaptopurine, cumulation of the latter is observed in the body, since due to the inhibition by allopurinol of the activity of xanthine oxidase, necessary for the biotransformation of drugs, their metabolism and elimination slows down.


It is a pharmaceutical drug. Use only as directed by your doctor.

Mode of application

Set individually, under the control of the concentration of urate and uric acid in the blood and urine. Adults with ingestion - 100-900 mg / day, depending on the severity of the disease. Frequency of admission 2-4 times / day after meals. Children under 15 years old - 10-20 mg / kg / day or 100-400 mg / day.
Maximum doses: in cases of impaired renal function (including those caused by uric nephropathy) - 100 mg / day. Increasing the dose is possible in cases when, against the background of therapy, an increased concentration of urates in the blood and urine is maintained.