Bicillin-3 powder for prig. solution for injection 600000 IU №1 fl.


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Bicillin-3 powder for prig. solution for injection 600000 IU number 1 fl.

Clinico-pharmacological groupAntibacterial agents

Pharmacotherapeutic group

antibiotic penicillin biosynthetic


Bitsillin - 3

International non-proprietary name

benzathine benzylpenicillin + benzylpenicillin procaine + benzylpenicillin

Dosage Form

powder for suspension for intramuscular injection

The composition of one bottle:

600,000 U, 1,200,000 U

Active substance:

benzathine benzylpenicillin 200,000 U 400,000 U
benzylpenicillin sodium (benzylpenicillin sodium salt)
or benzylpenicillin potassium (benzylpenicillin potassium salt)
200,000 U 400,000 U
benzylpenicillin procaine (benzylpenicillin novocaine salt) 200,000 U 400,000 U


Combined bactericidal preparation of 3 salts of benzylpenicillin: dibenzyl-ethylene diamine, procaine, sodium or potassium, with a long-lasting effect. Suppresses the synthesis of cell walls of microorganisms.
Active against gram-positive pathogens:
Staphylococcus spp. (non-educational penicillinase),
Streptococcus spp., Including Streptococcus pneumoniae,
Corynebacterium diphtheriae,
anaerobic spore-forming sticks:
Clostridium spp., Bacillus anthracis, Actinomyces Israel;
Gram-negative microorganisms:
Neisseria gonorrhoeae, Neisseria meningitidis, Treponema spp.
The drug resistant strains of Staphylococcus spp., Forming penicillinase.


After intramuscular injection, it is slowly absorbed to release benzylpenicillin from the depot. With a single injection is maintained at an average therapeutic concentration of 6-7 days. The time required to reach the maximum concentration (TCmax) in plasma is 12--24 h after injection. On the 14th day after the administration of 2.4 million ED, the serum concentration is 0.12 mcg / ml; on day 21 after administration of 1.2 million U - 0.06 mcg / ml (1 U = 0.6 mcg). Penetration in fluid is high, in tissue - low. Communication with plasma proteins - 40-60%. Gets through a placental barrier, it is found in mother's milk. Metabolized slightly, mainly excreted by the kidneys in unchanged form.

Indications for use

Infections (in adults) caused by susceptible microorganisms: syphilis and other diseases caused by pale treponema (yaws), streptococcal infections (excluding infections in group B streptococcus) - acute tonsillitis, scarlet fever, wound infections, erysipelas; rheumatism (prevention).
Contraindications Hypersensitivity to drugs of the penicillin group, etc. beta-lactam antibiotics, to procaine.

With caution: pregnancy, lactation, renal failure, allergic diseases, including bronchial asthma, pollinosis (including history), pseudomembranous colitis.

Use during pregnancy

Use during pregnancy is possible only when the intended benefit to the mother outweighs the potential risk to the fetus. If necessary, the use of the drug during lactation should decide on the termination of breastfeeding.
Dosage and administration Enter deeply intramuscularly in the upper outer quadrant of the gluteus muscle at a dose of 300 thousand units. If necessary, 2 injections are made into different buttocks. Repeated injections produced on 4 days after the previous injection.
At a dose of 600 thousand units enter 1 time in 6 days.

In the treatment of primary and secondary syphilis, a single dose of the drug is 1.8 million U. The course of treatment consists of 7 injections. The first injection is carried out in a dose of 300 thousand U.S., the second injection - after 1 day in a full single dose, subsequent injections are carried out 2 times a week in a full single dose.

In the treatment of secondary recurrent and latent early syphilis, a dose of 300 K units is used for the first injection, and 1.8 mln. ED for subsequent injections. Injections are carried out 2 times a week. The course of treatment is 14 injections.

Release form

Powder for the preparation of suspensions for intramuscular injection of 600,000 IU, 1,200,000 IU.

On 600000 PIECES and 1200000 PIECES in bottles with a capacity of 10 ml.
1, 5 or 10 bottles together with the application instruction in a pack cardboard.

Storage conditions

List B. In a dry place at a temperature of from 8 to 15 ° C. Keep out of reach of children.

Shelf life of 3 years.
Do not use after expiration date.

It is a pharmaceutical drug. Use only as directed by your doctor.