Ciprofloxacin 500mg №10 pills
Composition and release formCiprofloxacin coated pills - round, orange, biconvex.
1 tablet contains ciprofloxacin hydrochloride (in terms of ciprofloxacin) - 250 or 500 mg;
10, 20 pcs. packaged.
pharmachologic effectCiprofloxacin is a broad-spectrum antimicrobial agent from the group of fluoroquinolones. Bactericidal effect. The drug inhibits the enzyme DNA gyrase of bacteria, as a result of which DNA replication and synthesis of cellular proteins of bacteria are violated. Ciprofloxacin acts both on the breeding microorganisms and on those in the resting phase.
Ciprofloxacin is active against Gram-negative aerobic bacteria: Escherichia coli, Salmonella spp., Shigella spp., Citrobacter spp., Klebsiella spp., Enterobacter spp., Proteus mirabilis, Proteus vulgaris, Serratia marcescens, Hafnia alvei, i'm, i'm, as a real, Hafnia algaris, Serratia marcescens sf. Morganella morganii, Vibrio spp., Yersinia spp., Haemophilus spp., Pseudomonas aeruginosa, Moraxella catarrhalis, Aeromonas spp., Pasteurella multocida, Plesiomonas shigelloides, Campylobacter jejuni, neyo, neyo-cida, Pisiomonas shigelloides; intracellular pathogens: Legionella pneumophila, Brucella spp., Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium tuberculosis, Mycobacterium kansasii, Mycobacterium avium-intracellulare; Gram-positive aerobic bacteria: Staphylococcus spp. (Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus), Streptococcus spp. (Streptococcus pyogenes, Streptococcus agalactiae). Most methicillin-resistant staphylococci are also resistant to ciprofloxacin.
Streptococcus pneumoniae, Enterococcus faecalis are moderately sensitive to the drug.
Corynebacterium spp., Bacteroides fragilis, Pseudomonas cepacia, Pseudomonas maltophilia, Ureaplasma urealyticum, Clostridium difficile, Nocardia asteroides are resistant to the drug.
The effect of the drug on Treponema pallidum is not well understood.
Infectious and inflammatory diseases caused by susceptibility to the drug by microorganisms:
ear, nose and throat;
kidney and urinary tract;
genital organs (including gonorrhea, prostatitis);
gynecological (including adnexitis) and postpartum infections;
digestive system (including oral cavity, teeth, jaws);
gallbladder and biliary tract;
skin, mucous membranes and soft tissues;
ContraindicationsHypersensitivity to Ciprofloxacin or other drugs from the group of fluoroquinolones; glucose-6-phosphate dehydrogenase deficiency; pseudomembranous colitis; children's age up to 18 years (until the completion of the skeleton formation process); pregnancy; lactation period (breastfeeding).
With caution should be prescribed the drug in patients with severe atherosclerosis of the brain, cerebral circulation disorders, mental illness, convulsive syndrome, epilepsy, severe renal and / or hepatic insufficiency, elderly patients.
Dosage and administrationThe dose of Ciprofloxacin depends on the severity of the disease, the type of infection, the condition of the body, the age, weight and kidney function of the patient.The recommended doses are: Ciprofloxacin in the dosage form of pills 250 mg and 500 mg for oral administration:
Uncomplicated diseases of the kidneys and urinary tract - 250 mg, and in complicated cases, 500 mg, 2 times a day;
Diseases of the lower respiratory tract of moderate severity - 250 mg, and in more severe cases, 500 mg, 2 times a day;
For the treatment of gonorrhea, a single dose of Ciprofloxacin at a dose of 250-500 mg is recommended;
Gynecological diseases, enteritis and colitis with severe and high temperature, prostatitis, osteomyelitis - 500 mg 2 times a day (for the treatment of banal diarrhea, you can use a dose of 250 mg 2 times a day).
The drug should be taken on an empty stomach, drinking plenty of liquids. Patients with severe impaired renal function should be given a half dose of the drug. The duration of treatment depends on the severity of the disease, but treatment should always continue for at least another two days after the disappearance of the symptoms of the disease. Usually the duration of treatment is 7-10 days.
Side effectOn the part of the digestive system: nausea, diarrhea, vomiting, abdominal pain, flatulence, anorexia, cholestatic jaundice (especially in patients with past liver diseases), hepatitis, hepatonecrosis.
CNS and peripheral nervous system: dizziness, headache, fatigue, anxiety, tremor, insomnia, nightmarish dreams, peripheral paralgesia (anomaly of pain), sweating, increased intracranial pressure, anxiety, confusion, depression, hallucinations , manifestations of psychotic reactions (sometimes progressing to states in which the patient may harm himself), migraine, syncope, cerebral artery thrombosis.
On the part of the senses: impaired taste and smell, impaired vision (diplopia, change in color perception), noise in the ears, hearing loss.
Since the cardiovascular system: tachycardia, cardiac arrhythmias, lower blood pressure, rush of blood to the skin of the face.
On the part of the hematopoietic system: leukopenia, granulocytopenia, anemia, thrombocytopenia, leukocytosis, thrombocytosis, hemolytic anemia.
From laboratory parameters: hypoprothrombinemia, increased activity of hepatic transaminases and alkaline phosphatase, hypercreatininemia, hyperbilirubinemia, hyperglycemia.
On the part of the urinary system: hematuria, crystalluria (especially with alkaline urine and low diuresis), glomerulonephritis, dysuria, polyuria, urinary retention, albuminuria, urethral bleeding, hematuria, reduced nitrogen-excreting kidney function, interstitial nephritis.
On the part of the musculoskeletal system: arthralgia, arthritis, tendovaginitis, tendon ruptures, myalgia.
Allergic reactions: pruritus, urticaria, blistering, accompanied by bleeding, papules that form scabs, drug fever, punctate hemorrhages (petechiae), swelling of the face or larynx, shortness of breath, eosinophilia, increased photosensitivity, vasculitis, erythema, erectile dyspnea, eosinophilia, increased photosensitivity, vasculitis, erythema, erythema, ecology, eosinophilia, increased photosensitivity, vasculitis, erythema, erectile dyspnea, eosinophilia, increased photosensitivity, vasculitis, erythema, erectile dyspnea, eosinophilia, increased photosensitivity, vasculitis, erythema, erecima Stevens-Johnson, toxic epidermal necrolysis (Lyell's syndrome).
Others: general weakness, superinfection (candidiasis, pseudomembranous colitis).
Pregnancy and lactation
Ciprofloxacin is contraindicated for use during pregnancy and lactation (breastfeeding).
special instructionsIf severe and prolonged diarrhea occurs during or after treatment with Ciprofloxacin, diagnosis of pseudomembranous colitis should be excluded, which requires immediate discontinuation of the drug and appropriate treatment.
If you experience pain in the tendons or the first signs of tendovaginitis appear, treatment should be stopped.
During the period of treatment with Ciprofloxacin, it is necessary to provide a sufficient amount of fluid while observing normal diuresis.
During treatment with Ciprofloxacin, avoid contact with direct sunlight.
Influence on ability to drive motor transport and control mechanisms
Patients taking Ciprofloxacin, should be careful when driving a car and doing other potentially dangerous activities that require increased attention and quickness of psychomotor reactions (especially while drinking alcohol).
OverdoseTreatment: The specific antidote is unknown. It is necessary to carefully monitor the condition of the patient, make a gastric lavage, carry out the usual emergency measures, to ensure adequate intake of fluid.With the help of hemo- or peritoneal dialysis, only an insignificant (less than 10%) amount of the drug can be derived.
Storage conditionsList B. The drug should be stored in a dark place at a temperature not lower than 25 ° C, in places inaccessible to children.
Shelf life - 3 years.
It is a drug. Consultation with a doctor is required.