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Flagyl 250mg №20 pills

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Aquametro, Apo-Metronidazole, Arilin, Gene-Zolerol, Deflamon, Zoacid, Kamezol, Klion, Medazol, Metrovit, Metrogyl, Metroxan, Metrolaker, Metron, Metronidazole, Metronidazole in / in Brown, Metronidazole Qualimed, Metronidazole, and Metronidazole, as well as Metronidazole; Metronidazole-Ros, Metronidazole-Rusfar, Metronidazole-Teva, Metronidazole benzoate, Metroseptol, Nidazole, Novo-Nidazole, Orvagil, Protamet, Rozamet, Trikhazol, Tricho-PIN, Trichobrol, Trichopex, Trichopol, Filmet, Efflo,

The active substance is metronidazole.

pharmachologic effect
Antibacterial, antiprotozoal (trichomonacid), anti-ulcer, anti-alcohol. The nitrogroup of the molecule, which is an electron acceptor, is embedded in the respiratory chain of protozoa and anaerobes, which disrupts respiratory processes and causes cell death. In addition, in some types of anaerobes, it has the ability to inhibit DNA synthesis and cause its degradation. After ingestion quickly and completely absorbed from the digestive tract. The maximum concentration is reached in 1-2 hours. It penetrates well into tissues and body fluids, creating bactericidal concentrations in saliva, seminal fluid, vaginal secretions; penetrates the BBB and placental barriers, is secreted into breast milk. At repeated receptions cumulates. Subjected to biotransformation in the liver. Excreted by the kidneys and intestines, with about 20% unchanged. The spectrum of action includes the simplest: Trichomonas vaginalis, Entamoeba histolytica; anaerobic gram-negative microorganisms: bacteroids, including the Bacteroides fragilis group (B. fragilis, B. caccae, B. uniformis, B. distasonis, B. ovatus, B. thetaiotaomicron, B. vulgatus); Fuzobakterii Prevotella (P. bivia, P. buccae, P. disiens); anaerobic gram-positive bacilli: Clostridium, Eubacterium; anaerobic gram-positive cocci: Peptococcus, Peptostreptococcus; Trichomonacid effect is observed at a drug concentration of 2.5 mcg / ml for 24 hours. It is active against Helicobacter pylori.

Indications for use
Amebiasis, trichomoniasis, giardiasis, giardiasis, intra-abdominal infections (peritonitis, abscess), anaerobic infections of bones and joints, skin and soft tissues, female genitals (endometritis, tubo-ovarian abscess), central nervous system (meningitis, brain abscess, central nervous system (swelling of the brain, abscesses, endometritis, tubo-ovarian abscess), central nervous system (meningitis, brain abscess) , empyema, lung abscess), endocarditis, pseudomembranous colitis, Helicobacter pylori eradication, chronic alcoholism, prevention of postoperative anaerobic infection. For external and local use: pink and acne vulgaris, bacterial vaginosis, nonhealing wounds, trophic ulcers.

Hypersensitivity (including to other nitroimidazole derivatives), pregnancy, lactation, childhood (excluding cases of amebiasis).

Side effect
Headache, dizziness, syncopal states, ataxia, impaired consciousness, epileptic seizures, neutropenia (leukopenia), nausea, vomiting, abdominal pain, diarrhea, unpleasant metallic taste, erythematous rashes, skin itching, dark urine staining, allergic reactions, thrombophlebitis (after the on / in the introduction).

Enhances the effects of indirect anticoagulants and lithium salts. Phenytoin and phenobarbital reduce the action (due to the activation of the microsomal system of the liver and accelerate metabolism and excretion), and cimetidine increases (inhibits the enzymatic systems of the liver and, as a result, slows down biotransformation). Incompatible with alcohol (with a joint reception develops antabus-like syndrome).

Symptoms: nausea, vomiting, ataxia, in severe cases - peripheral neuropathy and seizures. Treatment: symptomatic; specific antidotes are absent.

Dosing and Administration
Inside, during or after a meal. Amebiasis: for adults - 600-800 mg 3 times a day for 8-10 days; children - 35-50 mg / kg per day, in 3 doses for 8-10 days. Giardiasis: 15 mg / kg per day, in 3 doses for 5 days. Trichomoniasis: Adults on 400 mg 2 times a day for 5-8 days (if necessary, a repeated course in 4-6 weeks) or once 2.0 g or 250 mg 2 times a day for 10 days; simultaneous treatment of both partners. Children: 2-5 years old - 250 mg per day, 5-10 years - 250-375 mg per day, older than 10 years - 500 mg per day, while the daily dose is divided into 3 doses. Giardiasis: Adults - 400 mg 3 times a day for 5 days or 250 mg 2 times a day for 10 days; children: 2-5 years old - 250 mg per day, 5-10 years - 250-375 mg per day, over 10 years old - 500 mg per day, in 3 doses. After completion of treatment, a follow-up study on the completeness of the cure is performed in 2-3 months. Eradication of Helicobacter pylori: 500 mg 3 times a day for 7 days, always in combination with other drugs. Anaerobic infection: adults - 400 mg 3 times a day for 7-10 days; children up to 12 years old - 7.5 mg / kg 3 times a day. Chronic alcoholism: by mouth, at 0.5 g per day for 6 (not more) months.

special instructions
When treating with metronidazole, excessive development of the fungal flora of the vagina (candidiasis) is sometimes observed, which requires the prescription of antifungal drugs.

Storage conditions
In a cool, dry, dark place. List B.

It is a pharmaceutical drug. Use only as directed by your doctor.