Nitroxoline 50mg №50 tabl

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Nitroxoline 50mg №50 tabl

general characteristics

International and chemical names:

nitroxoline; 5 -nit-8-hydroxyquinoline.

Main physical and chemical properties:

round-coated pills, from orange to orange-red color, with a biconvex surface, lighter color blotches are allowed. On the transverse fault can be seen the core, surrounded by two layers of the shell.

Composition:

1 tablet contains nitroxolin - 50 mg;
excipients: potato starch, lactose monohydrate, calcium stearate, talc, aerosil, sugar, magnesium carbonate, povidone, titanium dioxide, tartrazine, ponco 4 R, beeswax, vaseline oil.

Pharmacotherapeutic group

Antimicrobial agents. 8-hydroxyquinoline derivatives.

Pharmacodynamics.

Nitroxoline is a broad-spectrum antimicrobial and antiprotozoal drug for the treatment of urinary tract infections. Nitroxoline selectively inhibits the synthesis of bacterial DNA, forms complexes with metal-containing microbial cell enzymes and acts as a gram-positive microorganism: Staphylococcus spp. (including S.aureus), Streptococcus spp. (including beta-hemolytic streptococci, Streptococcus pneumoniae, Enterococcus faecalis), Corynebacterium spp., Bacillus subtilis; and gram-negative microorganisms: N.gonorrhoeae, E.coli, Proteus spp., Klebsiella spp., Salmonella spp., Shigella spp., Enterobacter spp.
Nitroxoline is also active against Mycobacterium tuberculosis, Trichomonas vaginalis, some species of fungi (Candida spp., Dermatophytes, molds, some causative agents of deep mycoses).

Pharmacokinetics.

After ingestion, nitroxoline is well absorbed from the digestive tract. Excreted mainly by the kidneys in unchanged form. With a single dose of 100 mg of the drug, the minimum bacteriostatic concentration in the urine lasts up to 3 hours, after taking 400 mg - up to 7 hours.

Indications for use

Acute and chronic infections of the kidneys and urinary tract caused by microorganisms sensitive to it (cystitis, pyelonephritis, urethritis, epididymitis, prostatitis), and also for the prevention of infections after kidney and urinary tract operations, for the prevention of infectious complications during diagnostic and therapeutic manipulations (catheterization , cystoscopy).

Dosage and administration

Nitroxoline is taken orally during or after a meal. The daily dose for adults is 400 mg (100 mg 4 times a day). In severe cases, the daily dose can be increased to 600 - 800 mg. The highest daily intake for adults is 800 mg. The course of treatment is 2 - 3 weeks.The average daily dose of Nitroxoline for children from 3 to 5 years is 200 mg, for children over 5 years old - 200 - 400 mg. The daily dose is divided into 4 doses. Duration of treatment 2 to 3 weeks.
In chronic infections of the urinary tract, Nitroxoline can be prescribed by repeated courses within 2 weeks with a two-week break. In order to prevent infections after kidney and urinary tract operations, Nitroxoline is prescribed 100 mg per dose 4 times a day for 2 to 3 weeks.

Side effect

Dyspeptic symptoms (nausea, vomiting), allergic reactions (skin rashes) are possible. In some cases - tachycardia, ataxia, headache, paresthesia, polyneuropathy, abnormal liver function.
With prolonged use, peripheral neuritis, myelopathy, damage to the optic nerve can develop. Phenomena of a possible accumulation of the drug are manifested in the form of nausea, vomiting, and general weakness, which usually pass on their own after discontinuation of the drug.

Contraindications

The use of Nitroxoline is contraindicated in case of hypersensitivity to other drugs of the quinoline series, cataract, neuritis, polyneuritis, during pregnancy and lactation, in acute and chronic renal failure, liver failure, glucose-6-phosphate dehydrogenase deficiency.

Overdose

There have been no reports of cases of Nitroxoline overdose.

Application features

When treated with Nitroxoline, urine is stained saffron yellow.
There is no evidence that the drug can adversely affect drivers and people working with equipment.

Interaction with other drugs

When Nitroxoline is combined with drugs of the tetracycline group, there is a summation of the effects of each drug, with nystatin and levorin - potentiation of action. To avoid the summation of a negative neurotropic effect, Nitroxolin cannot be combined with nitrofurans.



It is a pharmaceutical drug. Use only as directed by your doctor.