Oxamp sodium 333.5 mg + 166.5 mg powder №1

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Oxamp sodium 333.5 mg + 166.5 mg powder No. 1

Powder for the preparation of the solution for the / m the introduction of white with a yellowish tint, hygroscopic.

- 1 fl.
ampicillin (in the form of sodium salt) - 333.5 mg
oxacillin (in the form of sodium salt) - 166.5 mg

Clinico-pharmacological group:

An antibiotic of the penicillin group of a wide spectrum of action resistant to penicillinase

Pharmaco-therapeutic group:

Combined antibiotic (semi-synthetic penicillins)

Indications

Bacterial infections caused by susceptible pathogens: sinusitis, tonsillitis, otitis media; bronchitis, pneumonia; cholangitis, cholecystitis; pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, cervicitis; infections of the skin and soft tissues: erysipelas, impetigo, secondarily infected dermatosis, etc.

Prevention of postoperative complications during surgical interventions (including against the background of immunodeficiency), infections in the newborn (infection of the amniotic fluid; respiratory failure of the newborn, requiring resuscitation; the risk of aspiration pneumonia).

Severe infections (sepsis, endocarditis, meningitis, postpartum infection).
 

Dosing regimen

Inside, a single dose for adults and children over 14 years old - 0.5-1 g, daily - 2-4 g. Children 3-7 years old - 100 mg / kg / day, 7-14 years old - 50 mg / kg / day. The duration of treatment is from 5-7 days to 2 weeks. The daily dose is divided into 4-6 receptions.

V / m and / in (jet, drip), the daily dose for adults and children over 14 years - 3-6 g; for newborns, premature babies and children up to 1 year old - 100-200 mg / kg / day; 1-6 years - 100 mg / kg / day; 7-14 years - 100 mg / kg / day. The daily dose is administered in 3-4 doses, with an interval of 6-8 hours. If necessary, these doses can be increased by 1.5-2 times.

For intramuscular injection, the contents of the vial (0.2 and 0.5 g) are dissolved, respectively, in 2 and 5 ml of water for injection.

For iv injection (within 2-3 minutes), a single dose is dissolved in 10-15 ml of water for injection or 0.9% NaCl solution.

For intravenous drip in adults, a single dose is dissolved in 100-200 ml of 0.9% NaCl or 5% dextrose solution and injected at a rate of 60-80 drops / min; 30-100 ml of 5-10% dextrose solution is used as a solvent for children. In / in the drug injected 5-7 days, followed by a transition to the / m or oral administration.

The solutions are used immediately after preparation.

Side effect

Allergic reactions: urticaria, skin flushing, angioedema, rhinitis, conjunctivitis; fever, arthralgia, eosinophilia, in rare cases - anaphylactic shock; superinfection, dysbacteriosis, change in taste, vomiting, nausea, diarrhea, rarely - pseudomembranous enterocolitis, leukopenia, neutropenia, anemia.

Phlebitis and periphlebitis (with a / in the introduction); with v / m - at the injection site, infiltration, pain.

If signs of anaphylactic shock appear, urgent measures should be taken to remove the patient from this condition: administration of epinephrine, GCS (hydrocortisone or prednisolone) and antihistamine drugs, if necessary, ventilator.

Contraindications

- hypersensitivity;
- Infectious mononucleosis;
- lymphocytic leukemia.
With care: chronic renal failure, children born to mothers with hypersensitivity to penicillins.

Use during pregnancy and lactation
May be used during pregnancy according to indications.

Excreted in breast milk in low concentrations. If necessary, the use of the drug during lactation should decide on the termination of breastfeeding.

Application for violations of the liver
During the course of treatment it is necessary to monitor the state of the liver function.

Application for violations of kidney function
When used in high doses in patients with renal insufficiency, a toxic effect on the central nervous system is possible. In the course of treatment it is necessary to monitor the state of renal function.

Use in children
Use with caution in children born to mothers with hypersensitivity to penicillins. Apply according to indications.

special instructions

In the course of treatment it is necessary to monitor the state of the function of the blood-forming organs, liver and kidneys.

The possibility of the development of superinfection (due to the growth of microflora insensitive to it) requires a corresponding change in antibacterial therapy.

In patients with hypersensitivity to penicillins, allergic cross-reactions with cephalosporin antibiotics are possible.

When used in high doses in patients with renal insufficiency, a toxic effect on the central nervous system is possible.

Drug interaction

Antacids, glucosamine, laxative drugs, food, aminoglycosides (with enteral administration) slow down and reduce absorption; ascorbic acid increases absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) have a synergistic effect; bacteriostatic drugs (macrolides, chloramphenicol, linkosamides, tetracyclines, sulfonamides) - antagonistic.

Increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index); reduces the effectiveness of oral contraceptives, drugs, in the process of metabolism which produces PABK, ethinyl estradiol - the risk of bleeding "breakthrough".

Diuretics, allopurinol, canalicular secretion blockers, phenylbutazone, NSAIDs, and other drugs that block tubular secretion, increase the concentration of the drug in plasma, which increases the risk of toxic action.

Allopurinol increases the risk of skin rash.



It is a pharmaceutical drug. Use only as directed by your doctor.