Sitrolide 250mg №100 caps.

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Sitrolide 250mg №100 caps.

Name:Zitrolid (Zitrolid)

Pharmachologic effect:

Sitrolide is an antimicrobial drug of the macrolide group. Sitrolide contains azithromycin - azalide, which has high antimicrobial activity. Azithromycin creates high concentrations in the focus of inflammation. Strains of Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus agalactiae, Staphylococcus aureus, Streptococcus viridans, Streptococcus group F, C and G are sensitive to the action of the drug Zitrolide.
In addition, Azithromyk Peptostreptococcus spp. and Clostridium perfringens.
The drug Zitrolid is effective in diseases caused by Chlamydia trachomatis, Borrelia burgdoferi, Mycoplasma pneumoniae, Ureaplasma urealyticum, Treponema pallidum.
There is cross-resistance between macrolide antibiotics.
After oral administration, azithromycin is rapidly absorbed in the digestive tract. The active ingredient of the drug Zitrolid is stable in the acidic environment of the stomach. Eating reduces the bioavailability of azithromycin somewhat (bioavailability when taken on an empty stomach is 37%). Peak plasma concentration is reached within 2.5-3 hours.
Azithromycin penetrates well into tissues and biological fluids of the body, high concentrations are created in inflamed tissues (due to the ability of azithromycin to bind to phagocytes, which deliver the active substance to the localization sites of the infection). Despite the high concentrations of azithromycin in phagocytes, the drug Zitrolid has no significant effect on their function. After taking the last dose, therapeutic concentrations of azithromycin are maintained for 5-7 days.
Metabolized in the liver by de-methylation, azithromycin metabolites do not possess pharmacological activity.
Excreted in two phases, the half-life for the first phase is from 8 to 24 hours, the second phase - from 24 to 72 hours.

Indications for use:

Zitrolid used for the treatment of patients with infectious diseases caused by pathogens sensitive to azithromycin. In particularNitrolide prescribed for:
Infectious diseases of the respiratory tract and ENT organs (including otitis media, tonsillitis, pharyngitis, bronchitis and non-hospital pneumonia).
Infectious diseases of soft tissues and skin (including impetigo, secondary infected dermatitis, secondary pyoderma, as well as the initial stage of Lyme disease).
Uncomplicated infectious diseases of the urogenital tract.
In addition, nitrolide is prescribed in Helicobacter pylori eradication regimens.

Side effects:

When taking the drug Zitrolid in patients may develop such undesirable effects due to azithromycin:
On the part of the hepatobiliary system and the digestive tract: pain in the abdominal region, vomiting, diarrhea, dyspeptic symptoms, melena, change in taste, flatulence, jaundice with cholestasis, increased activity of liver enzymes. Predominantly in children may develop gastritis, constipation and loss of appetite.
From the vessels and the heart: pain in the chest, heartbeat, heart rhythm disturbances.
On the part of the nervous system: drowsiness, hyperkinesia, increased anxiety, neurosis, dizziness, sleep disorders, increased fatigue.
On the part of the blood system: eosinophilia, neutropenia (these effects, as a rule, disappear on their own within 2-3 weeks after the end of azithromycin therapy).
From the genitourinary system: vaginal candidiasis, nephritis.
Allergic reactions: photosensitivity, pruritus, urticaria, angioedema, allergic conjunctivitis, erythema multiforme, anaphylactic shock.
In addition, when taking azithromycin may develop hyperglycemia.

Contraindications:

Zitrolid not used for the treatment of patients with known hypersensitivity to azithromycin and other antimicrobial agents of the macrolide group.
Zitrolid should not be prescribed to patients with impaired renal function and liver.
In pediatric practice, Zitrolide capsules are used only for treating children over 12 years old.
Zitrolid should be used with caution in patients with cardiac arrhythmias, as well as patients who receive drugs that extend the Q-T interval.
During the period of therapy with the drug Zitrolid, activities that require high concentration and speed of psychomotor reactions should be avoided.

Pregnancy:

During pregnancy, azithromycin may be prescribed only if the expected benefit to the mother greatly exceeds the potential risks to the fetus.
During lactation at the time of taking the drug Zitrolid should stop breastfeeding. You can restore breastfeeding no earlier than 7 days after taking the last dose of azithromycin.

Interaction with other drugs:

When combined with azithromycin intake with food, ethyl alcohol and antacid agents containing compounds of magnesium and aluminum, a decrease in the absorption rate and bioavailability of azithromycin is noted.
With simultaneous use of macrolides with warfarin may increase the severity of the anticoagulant effect. If necessary, the combined use of azithromycin with warfarin should monitor blood clotting.
Sitrolide while taking increases plasma concentrations of digoxin.
Azithromycin in combination may increase the toxicity of ergotamine and dihydroergotamine.
The drug can reduce the clearance of triazolam and increase the severity of its pharmacological effects.
Plasma concentrations of unchanged carbamazepine, terfenadine, hexobarbital, cyclosporine, valproic acid, phenytoin, bromocriptine, ergot alkaloids, oral hypoglycemic agents, and dysopyramide and xanthine derivatives can be increased when combined with azythromycin, in a mode, a limit, and a limit is not applied to the level, a limit, a limit, and a limit is applied to the level, a limit, a limit, and a limit, a limit, and a limit of 33% and 16% of the rest of the rest of the distance limit will not be applied. metabolism of the above means).
It is also possible to increase plasma concentrations and toxicity of indirect anticoagulants, cycloserine, felodipine and methylprednisolone when used in combination with the drug Zitrolid.
When combined with the use of linkosamines, the effectiveness of the drug Zitrolid decreases.
Tetracyclines and chloramphenicol with simultaneous use increase the effectiveness of azithromycin.

Overdose:

When taking excessive doses of the drug Zitrolid in patients may develop nausea, headache, vomiting, dyspeptic symptoms and temporary hearing loss, up to deafness.
There is no specific antidote. When taking the drug Zitrolid in doses significantly higher than the recommended, you should wash the stomach and take enterosorbent means. With the development of signs of overdose, the drug Zitrolid is canceled and, if necessary, symptomatic therapy is carried out.

Synonyms:

Azithromycin, Azitrus, Azitsin, Hemomitsin, Ormaks, Sumamed.



It is a pharmaceutical drug. Use only as directed by your doctor.

Composition

Composition:
1 capsule of the drug Zitrolid contains:
Azithromycin - 250 mg;
Additional ingredients.

Release form:
Zitrolid capsules of 6 pieces in a blister pack, in a cardboard bundle 1 blister pack.
Capsules Zitrolid Forte 3 pieces in a blister pack, in a cardboard bundle 1 blister pack.

Mode of application

Mode of application:
Sitrolid is intended for oral administration. Capsules should be swallowed whole 60 minutes before or 2 hours after a meal. Capsules are recommended to drink plenty of drinking water. The daily dose of the drug Zitrolid, as a rule, is prescribed for 1 reception. Azithromycin is recommended to be taken at regular intervals. The duration of therapy and the dose of azithromycin is determined by the attending physician.
In infectious diseases of the lower and upper respiratory tract adults, as a rule, 500 mg of azithromycin per day are prescribed. The duration of therapy is 3 days, the total course dose is 1500 mg of azithromycin.
In infectious diseases of the skin and soft tissues, as well as the initial stage of Lyme disease, adults usually receive 1000 mg of azithromycin on the first day of therapy, then proceed to receive 500 mg of azithromycin per day. The duration of the course is 5 days, the total course dose of 3000 mg of azithromycin.
In acute and uncomplicated diseases of the genitourinary system, adults usually receive 1000 mg of azithromycin once.
For ulcerative lesions of the stomach and duodenum associated with Helicobacter pylori, adults usually receive 1000 mg of azithromycin per day in combination with other drugs. The duration of azithromycin is 3 days.
Children with a body weight of more than 45 kg, as a rule, are prescribed azithromycin in doses recommended for adults.
When skipping the next dose of azithromycin should be taken as soon as possible, the next dose in this case is taken after 24 hours.

Storage conditions:
The drug Zitrolid should be stored in the original packaging at a temperature of 15 to 25 degrees Celsius.
Shelf life of the drug Zitrolid indicated on the package.