Supraks Solyutab 400mg №7 pills

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Supraks Solyutab 400mg №7 pills

pharmachologic effect

Semisynthetic cephalosporin III generation antibiotic for oral administration of a wide spectrum of action. Bactericidal effect. The mechanism of action is due to inhibition of the synthesis of the cell membrane of the pathogen. Cefixime is resistant to beta-lactamase produced by most gram-positive and gram-negative bacteria.
In vitro, cefixime is active against gram-positive bacteria: Streptococcus agalactiae; Gram-negative bacteria: Haemophilus parainfluenzae, Proteus vulgaris, Klebsiella pneumoniae, Klebsiella oxytoca, Pasteurella multocida, Providencia spp., Salmonella spp., Shigella spp., Citrobacter amalonaticus, Citrobacter diversus-synsus, an example, Syro.
In vitro and in clinical practice, cefixime is active against gram-positive bacteria: Streptococcus pneumoniae, Streptococcus pyogenes; Gram-negative bacteria: Haemophilus influenzae, Moraxella (Branhamella) catarrhalis, Escherichia coli, Proteus mirabilis, Neisseria gonorrhoeae.
Pseudomonas spp., Enterococcus (Streptococcus) serogroup D, Listeria monocytogenes, most of Staphylococcus spp. (including methicillin-resistant strains), Enterobacter spp., Bacteroides fragilis, Clostridium spp.

Pharmacokinetics

Suction and distribution
When taken orally, the bioavailability of cefixime is 40-50% regardless of food intake, however, Cmax cefixime in serum is achieved by 0.8 h faster when taking the drug with food.
When taking the drug in the form of capsules in a dose of 200 mg Cmax in serum is reached after 4 hours and is 2 μg / ml, when taken at a dose of 400 mg - 3.5 μg / ml.
When taking the drug in the form of a suspension in a dose of 200 mg Cmax in serum is reached after 4 hours and is 2.8 μg / ml), when taken in a dose of 400 mg - 4.4 μg / ml.
Binding to plasma proteins, mainly albumin, is 65%.
Removal
About 50% of the dose is excreted in the urine unchanged for 24 hours, about 10% of the dose is excreted in the bile.
T1 / 2 depends on the dose and is 3-4 hours.
Pharmacokinetics in special clinical situations
In patients with impaired renal function with CK 20–40 ml / min, T1 / 2 increases to 6.4 h, with CK 5–10 ml / min - to 11.5 h.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:
- pharyngitis;
- tonsillitis;
- sinusitis;
- acute and chronic bronchitis;
- otitis media;
- uncomplicated urinary tract infections;
- gonococcal infection of the urethra and cervix.

Dosing regimen

For adults and children over 12 years old with a body weight of more than 50 kg, the daily dose is 400 mg (1 time / day or 200 mg 2 times / day). Duration of treatment is 7-10 days.
For uncomplicated gonorrhea of ​​the urethra and cervix, 400 mg is administered once.
For children aged 6 months to 12 years, the drug is prescribed as a suspension in a dose of 8 mg / kg of body weight 1 time / day or 4 mg / kg every 12 hours.
For children aged 5-11 years, the daily dose is 6-10 ml, at the age of 2-4 years - 5 ml, at the age of 6 months to 1 year - 2.5-4 ml.
For infections caused by Streptococcus pyogenes, the treatment should be at least 10 days.
In case of impaired renal function (with CC 21-60 ml / min) or in patients on hemodialysis, the daily dose should be reduced by 25%. When QC <= 20 ml / min or in patients on peritoneal dialysis, the daily dose should be reduced by 2 times.
Suspension preparation rules
Flip the bottle and shake the powder. Add 40 ml of boiled water cooled to room temperature in 2 stages and shake after each addition to form a homogeneous suspension. After that, it is necessary to allow the suspension to settle for 5 minutes to ensure full suspension of the powder. Before use, the finished suspension should be shaken.

Side effect

On the part of the digestive system: dry mouth, anorexia, diarrhea, nausea, vomiting, abdominal pain, flatulence, a transient increase in liver transaminases and alkaline phosphatase, hyperbilirubinemia, jaundice, candidiasis of the gastrointestinal tract, dysbacteriosis; rarely - stomatitis, glossitis, pseudomembranous colitis.
On the part of the hemopoietic system: leukopenia, thrombocytopenia, neutropenia, hemolytic anemia.
From the side of the central nervous system: dizziness, headache.
On the part of the urinary system: interstitial nephritis.
Allergic reactions: pruritus, urticaria, skin flushing, eosinophilia, fever.

Contraindications

- hypersensitivity to cephalosporins and penicillins.

Pregnancy and lactation

Use of Supraksa during pregnancy is possible only when the intended benefit to the mother outweighs the potential risk to the fetus.
If necessary, use Supraksa during lactation should stop breastfeeding.

special instructions

With caution, Suprax should be prescribed to elderly patients, patients with chronic renal failure or pseudomembranous colitis (in history), children under 6 months.
With long-term use of the drug may disrupt the normal intestinal microflora, which can lead to an increase in Clostridium difficile and cause the development of severe diarrhea and pseudomembranous colitis.
Patients with a history of allergic reactions to penicillins, may show increased sensitivity to cephalosporin antibiotics.
During treatment, a positive direct Coombs reaction and a false-positive reaction of urine to glucose are possible.

Overdose

Symptoms: increased manifestations of the described side effects.
Treatment: gastric lavage; carry out symptomatic and supportive therapy, which, if necessary, includes the use of antihistamines, glucocorticoids, pressor amines, oxygen therapy, transfusion of infusion solutions, mechanical ventilation.
Hemodialysis and peritoneal dialysis are ineffective.

Drug interaction

Clinically significant drug interaction of the drug Supraks with other drugs is not installed.

Terms and conditions of storage

List B. The drug should be stored out of the reach of children at a temperature of 15 ° to 25 ° C. Shelf life - 3 years.
Pharmacy sales terms
The drug is available on prescription.

It is a pharmaceutical drug. Use only as directed by your doctor.