Tinidazole Acry 500mg №4 pills

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Tinidazole Acry 500mg №4 pills

pharmachologic effect

Tinidazole- antiprotozoal drug with antibacterial action. The mechanism of action is due to inhibition of synthesis and damage to the DNA structure of pathogens.
Active against Trichomonas vaginalis, Entamoeba histolytica, Lamblia intestinalis. It has a bactericidal effect against the following aerobic bacteria: Bacteroides spp. (including Bacteroides fragilis, Bacteroides melaninogenicus), Clostridium spp., Eubacterium spp., Fusobacterium spp., Peptococcus spp., Peptostreptococcus spp., Veillonella spp.

Indications

- trichomoniasis;
- giardiasis;
- amebiasis (including hepatic form);
- infections caused by anaerobic bacteria;
- mixed aerobic-anaerobic infections (in combination with antibiotics);
- Eradication of Helicobacter pylori (in combination with bismuth preparations and antibiotics).

The drug is used to prevent postoperative infectious complications caused by anaerobes.

Contraindications

- organic diseases of the central nervous system;
- violations of blood formation;
- I trimester of pregnancy;
- lactation (breastfeeding);
- hypersensitivity to the drug or other derivatives of 5-nitroimidazole.

Side effect

On the part of the digestive system: possible anorexia, dryness and unpleasant taste in the mouth, nausea, vomiting, diarrhea.
From the side of the central nervous system and peripheral nervous system: headache, dizziness, ataxia, peripheral neuropathy; rarely convulsions.
Allergic reactions:urticaria, pruritus, skin rash, angioedema.
Other:rarely, transient leukopenia, weakness.

Pregnancy and lactation

Tinidazole is contraindicated for use in the first trimester of pregnancy. Use of the drug in the II and III trimesters is possible only in cases where the intended benefit to the mother outweighs the potential risk to the fetus.
If necessary, use Tinidazole during lactation should decide on the termination of breastfeeding. It should be borne in mind that tinidazole is determined in breast milk for 72 hours after ingestion.

special instructions

In the treatment of trichomoniasis should be the simultaneous treatment of both sexual partners.
If adverse reactions from the CNS occur, Tinidazole should be discontinued.
In the process of treatment with tinidazole should refrain from alcohol because of the possible development of antabus-like reactions.
The drug causes dark staining of urine.

Control of laboratory parameters
If treatment continues for more than 6 days, regular monitoring of the peripheral blood pattern should be carried out.
Influence on ability to drive motor transport and control mechanisms
Patients taking the drug should refrain from engaging in potentially hazardous activities that require increased attention and speed of psychomotor reactions.

Overdose

Currently, cases of overdose of the drug Tinidazole are not described.
Treatment: conduct symptomatic therapy. Tinidazole is eliminated during dialysis. There is no specific antidote.

Drug interaction

Enhances the effect of indirect anticoagulants (to reduce the risk of bleeding, reduce the dose by 50%) and the effect of ethanol (disulfiramopodobny effect).
Do not take with ethionamide. Phenobarbital accelerates metabolism. Compatible with sulfonamides and antibiotics (aminoglycosides, erythromycin, rifampicin, cephalosporins).


It is a pharmaceutical drug. Use only as directed by your doctor.

Composition

pills, film coated white or almost white, round, biconvex.
1 tablet contains tinidazole 500 mg;
Excipients: lactose, methyl hydroxybenzoate, corn starch, magnesium stearate, purified talcum, anhydrous colloidal silicon, Opadry white 04В 58909.
4 things. packaged.

Mode of application

With trichomoniasis and giardiasis, the drug is prescribed once to adults for 2 g (4 tab.) / Day; children at the rate of 50-75 mg / kg body weight per day. If necessary, the drug can be repeated in the same dose.
With intestinal amebiasis, the daily dose for adults is 2 g, the drug is taken 2-3 days. Tinidazole is prescribed for children at the rate of 50-60 mg / kg / day; treatment course is 3 days.
In adults with hepatic amebiasis, the drug is prescribed in an initial dose of 1.5-2 g / day. The course of treatment is 3 days, if necessary, the duration of therapy can be increased to 6 days. The course dose, depending on the severity of the infection, is 4.5-12 g. For children, Tinidazole is prescribed in doses of 50-60 mg / kg / day; the duration of therapy is 5 days.
When treating infections caused by anaerobic bacteria, adults on the first day of treatment are prescribed 2 g / day in 1 dose, then 1 g / day. Treatment continues for 5-6 days.For children under the age of 12, doses have not been established.
For the prevention of postoperative infectious complications, adults are prescribed 2 g once a day 12 hours before surgery. For children under the age of 12, doses have not been established.

Storage conditions
Store in a dry, dark place at temperatures not above 25 ° C.
Shelf life - 3 years.