Cetrin 10mg №30 pills

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Cetrin 10 mg №30 pills

pharmachologic effect 
Histamine H1 receptor blocker. Does not block cholinergic and serotonin receptors. It has an anti-allergic effect, when used in therapeutic doses does not penetrate the BBB, therefore does not cause any significant sedative effect. Cetirizine affects both the early and late stages of an allergic reaction.

Pharmacokinetics 
Suction and distribution
After oral administration cetirizine is well absorbed from the gastrointestinal tract. Reception simultaneously with food practically does not affect absorption. Cmax of cetirizine in the blood is reached 1 hour after administration and is 0.3 μg / ml. Cetirizine is largely bound to plasma proteins.
Metabolism and excretion
It is slightly metabolized in the liver. T1 / 2 is about 10 hours, in elderly people - about 12 hours, in children - 5-6 hours. Most cetirizine is excreted in the urine unchanged.
Pharmacokinetics in special clinical situations
T1 / 2 in the elderly is about 12 hours, in children - 5-6 hours.

Dosage 
For adults and children older than 6 years, the daily dose is 10 mg, for adults - in 1 reception, the drug is prescribed for children 5 mg 2 times / day. pills washed down with a small amount of water.
In case of impaired renal function, dose adjustment of the drug is required (as a rule, the dose is reduced by 2 times).

Overdose 
Symptoms: drowsiness; with a significant overdose of the drug (excess therapeutic dose 30-40 times in adults and children) - drowsiness, anxiety, itching, rash, urinary retention, fatigue, tremor, tachycardia. In all cases, there was a complete normalization of the state.
Treatment: gastric lavage; if necessary, symptomatic therapy. There is no specific antidote. Hemodialysis is ineffective.

Drug interaction 
So far, there is no data on the interaction of cetirizine with other drugs, however, caution should be exercised while prescribing the drug with sedatives.

Pregnancy and lactation 
The drug is contraindicated for use during pregnancy and lactation (breastfeeding).

Side effects 
From the side of the central nervous system: in some cases - weakness, headache, dizziness, drowsiness, psychomotor agitation.
On the part of the digestive system: dry mouth, disorders of the gastrointestinal tract.
Other: extremely rare - hypersensitivity reactions (skin rash, angioedema).
Cetrin is usually well tolerated.

Terms and conditions of storage 
List B. The drug should be stored in a dry, dark place and out of reach of children at a temperature not exceeding 25 ° C. Shelf life - 2 years.

Indications 
Cetrin is used in adults and children over the age of 6 years to alleviate the symptoms of:
- seasonal and chronic allergic rhinitis;
- allergic conjunctivitis;
- Itching of various etiologies;
- urticaria (including chronic idiopathic);
- angioedema (angioedema).

Contraindications 
- pregnancy;
- lactation (breastfeeding);
- hypersensitivity to the drug.

special instructions 
When used in therapeutic doses, cetirizine does not potentiate the action of ethanol, however, alcohol consumption during the use of the drug is not recommended.

Influence on ability to drive motor transport and control mechanisms
In therapeutic doses, Cetrin does not affect the speed of psychomotor reactions. However, patients involved in potentially hazardous activities need to be careful.

When kidney damage 
In case of impaired renal function, dose adjustment of the drug is required (as a rule, the dose is reduced by 2 times).

Use in childhood 
For children older than 6 years, the daily dose is 10 mg, for adults - in 1 reception, the drug is prescribed for children 5 mg 2 times / day. pills washed down with a small amount of water.

Pharmacy sales terms 
The drug is approved for use as a means of OTC.

It is a drug. Consultation with a doctor is required.