Upsarin UPSA 500mg №16 effervescent pills

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Upsarin UPSA 500mg №16 effervescent pills

Special features

Interaction:
It enhances the toxicity of methotrexate, reducing its renal clearance, the effects of other NSAIDs, narcotic analgesics, oral hypoglycemic drugs, reserpine, heparin, indirect anticoagulants, thrombolytics and platelet aggregation inhibitors, sulfanilamides (including co-trimmoxomas). reduces the effect of uricosuric drugs (benzbromarone, sulfinpyrazone), antihypertensive drugs, diuretics (spironolactone, furosemide). GCS, ethanol and ethanol-containing drugs increase the damaging effect on the gastrointestinal mucosa, increase the risk of gastrointestinal bleeding. Increases the concentration of digoxin, barbiturates, salts of Li + in the plasma. Antacids containing Mg2 + and / or Al3 + slow down and impair the absorption of ASA. Myelotoxic drugs increase the hematotoxicity of the drug.

Pharmaceutical action


NSAIDs. It has anti-inflammatory, analgesic and antipyretic effects, reduces mortality and the risk of myocardial infarction in unstable angina. It is effective in primary prevention of cardiovascular disease, especially myocardial infarction in men older than 40 years, and in secondary prevention of myocardial infarction.

Contraindications


Hypersensitivity; erosive and ulcerative lesions of the gastrointestinal tract, gastrointestinal bleeding; aspirin triad; hemorrhagic diathesis; dissecting aortic aneurysm, portal hypertension; vitamin K deficiency; hepatic / renal failure; pregnancy (I and III trimesters), lactation; deficiency of glucose-6-phosphate dehydrogenase, childhood (up to 15 years - the risk of Reye's syndrome in children with hyperthermia in the background of viral diseases).

special instructions

Duration of treatment (without consulting a doctor) should not exceed 7 days when prescribed as an analgesic drug and more than 3 days as an antipyretic. It is excreted in breast milk, which increases the risk of bleeding in a child due to dysfunction of platelets. ASA even in small doses reduces the excretion of uric acid from the body, which can cause the development of an acute attack of gout in predisposed patients. During the period of treatment should refrain from taking ethanol.



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Precautionary measures

Side effects:
Nausea, loss of appetite, gastralgia, diarrhea; allergic reactions (skin rash, angioedema, bronchospasm); impaired liver and / or kidney function; thrombocytopenia, anemia, leukopenia, Reye's syndrome (encephalopathy and acute fatty liver with rapid development of liver failure), the formation of "aspirin" asthma and "aspirin triad" based on the hapten mechanism and aspirin-wrinkle-sticking spider veins and drug pyrazolone series).


It is a pharmaceutical drug. Use only as directed by your doctor.

Mode of application


inside, previously having dissolved in a small amount of water, - on 400-800 mg 2-3 times a day (no more than 6 g). Effervescent pills are dissolved in 100-200 ml of water and taken orally, after meals, a single dose - 0.25-1 g, taken 3-4 times a day. The duration of treatment is from a single dose to a multi-month course. Cancellation is made gradually over 1-2 weeks.