Pantogam Active 300mg №60 capsules
PHARMACHOLOGIC EFFECTAction Pantogam asset is associated with the presence in its structure of gamma-aminobutyric acid, which directly affects the GABCR-receptor-channel complex. Pantogam active is a racemic mixture of equal amounts of the R-form of hopantenic acid and its S-isomer. The presence of an isomer improves the transport and interaction of the drug with the GABA receptor. Pantogat asset has a more pronounced nootropic and anticonvulsant effect than preparations of first-generation guantenic acid.
Pantogam active increases brain resistance to hypoxia and the effects of toxic substances, stimulates anabolic processes in neurons, combines a moderate sedative effect with a mild stimulating effect. It has antiasthenic and mild anti-anxiety action. Reduces motor excitability, streamlines behavior. Activates mental activity and performance. It causes inhibition of the pathologically increased gallbladder reflex and detrusor tone.
PHARMACOKINETICSRapidly absorbed from the digestive tract. It penetrates the blood-brain barrier. Not metabolized and excreted unchanged within 48 hours: about 70% of the dose - with urine, about 30% - with feces.
DOSAGEInside, 15-20 minutes after eating, 2-3 times / day, preferably in the morning and afternoon hours.
Capsules 200 mg - 1-4 capsules (0.2-0.8 g). The maximum daily dose is 12 capsules (2.4 g).
Capsules 300 mg - 1-3 capsules (0.3-0.9 g). The maximum daily dose of 8 capsules (2.4 g). The course of treatment is 1-4 months, sometimes up to 6-12 months. After 3-6 months, it is possible to repeat the course of treatment.
OVERDOSEStrengthening the symptoms of side effects.
Treatment: activated carbon, gastric lavage, symptomatic therapy.
DRUG INTERACTIONProlongs the action of barbiturates, enhances the effects of anticonvulsants, prevents the side effects of phenobarbital, carbamazepine, antipsychotics.
The effect of Pantogam active is enhanced when combined with glycine, etidronic acid.
Potentiates the action of local anesthetics (procaine).
PREGNANCY AND LACTATIONThe drug is contraindicated during pregnancy (I trimester) and during lactation.
SIDE EFFECTSIn rare cases, allergic reactions (rhinitis, conjunctivitis, skin rashes) are possible. In this case, reduce the dose or cancel the drug. Sleep disturbances or drowsiness, noise in the head - these symptoms are usually short-lived and do not require discontinuation of the drug.
TERMS AND CONDITIONSThe drug is stored in a dry, dark place at a temperature not exceeding 25 ° C. Keep out of the reach of children.
Shelf life - 3 years. Do not use after the expiration date printed on the package.
INDICATIONS- cognitive impairment with organic brain lesions (including the effects of neuroinfections and traumatic brain injuries) and neurotic disorders;
- cerebrovascular insufficiency caused by atherosclerotic changes of cerebral vessels;
- extrapyramidal hyperkinesis (myoclonus epilepsy, Huntington’s chorea, hepatolenticular degeneration, Parkinson’s disease and others), as well as for the treatment of extrapyramidal syndrome caused by the administration of neuroleptics;
- in case of epilepsy together with anticonvulsants;
- psycho-emotional overload, reduced mental and physical performance, to improve concentration and memorization;
- Neurogenic disorders of urination (pollakiuria, urgency, imperative urinary incontinence, enuresis);
- with schizophrenia in complex therapy.
CONTRAINDICATIONS- acute severe kidney disease;
- pregnancy (I term);
- the patient is under 18 years of age (there are no clinical studies on the use of the drug at this age);
- increased sensitivity.
SPECIAL INSTRUCTIONSIn conditions of long-term treatment, simultaneous administration of the drug with other nootropic and CNS-stimulating agents is not recommended.
IN CASE OF KIDNEY FUNCTION DISORDERSContraindicated in acute severe kidney disease.
APPLICATION IN CHILDRENContraindicated in children under 18 years, because There are no clinical studies on the use of the drug at this age.
CONDITIONS FOR VACATION FROM DRUGSTORESThe drug is available on prescription.
It is a pharmaceutical drug. Use only as directed by your doctor.