Baklosan 25mg №50 pills

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Baklosan 25mg №50 pills

pharmachologic effect

Muscle relaxant centrally acting; GABAB receptor agonist. Reducing the excitability of the terminal parts of afferent sensory fibers and suppressing intermediate neurons, inhibits the mono-and polysynaptic transmission of nerve impulses; reduces prestressing muscle spindles. Does not affect the transmission of impulses in the neuromuscular synapses. In neurological diseases accompanied by skeletal muscle spasticity, it relieves painful spasms and clonic convulsions. Increases the amount of movement in the joints, facilitates the holding of passive and active kinesitherapy (exercise, massage, manual therapy).

Pharmacokinetics

Suction
Absorption is high. Cmax in plasma is reached 2-3 hours after taking the drug.
Distribution
Plasma protein binding is about 30%. Baclofen crosses the placental barrier, is excreted in breast milk.
Metabolism
Metabolized in the liver.
Removal
Excreted in the urine, mostly unchanged.

Dosage

Inside, while eating. In the case of skipping the next reception should not take a double dose of the drug.
Adults
The initial dose is 5 mg 3 times / day, with a subsequent increase in the dose every 3 days at 5 mg until the onset of the therapeutic effect (usually up to 30-75 mg / day). The maximum daily dose is 100 mg.
The final dose is set so that the decrease in muscle tone does not lead to excessive myasthenia and does not impair motor function. With increased sensitivity, the initial daily dose is 5-10 mg, followed by a slower increase.
In chronic renal failure and during hemodialysis, the daily dose is 5 mg.
Patients requiring high doses of baclofen (from 75 mg to 100 mg per day) should use the drug in pills of 25 mg.
In patients older than 65 years, the dose should be increased with caution, due to the increased risk of side effects.
Children
The initial dose is 5 mg 3 times / day. If necessary, the dose can be carefully increased every 3 days by 5 mg until the onset of the therapeutic effect.
The following doses are generally recommended: in children from 3 to 6 years old - 20-30 mg / day, from 6 to 10 years old - 30-60 mg / day, in children over 10 years old, the maximum daily dose is 2.5 mg / kg body weight; The initial dose is 1.5-2 mg / kg body weight.
The abolition of the drug is carried out gradually (within 1-2 weeks).

Overdose

Symptoms: hypotonia, depression of the respiratory center, confusion, coma (after regaining consciousness, hypotension can persist for 72 hours).
Treatment: drink plenty of fluids, diuretic intake, respiratory depression - mechanical ventilation. There is no specific antidote.

Drug interaction

With simultaneous use of Baklosan enhances the effect of drugs that affect the central nervous system, antihypertensive, anti-gout agents, ethanol.
With simultaneous use of Baklosan with tricyclic antidepressants, a significant decrease in muscle tone is possible.
While taking Baklosan with levodopa and carbidopa, hallucinations, confusion, agitation can occur.

Pregnancy and lactation

The drug is contraindicated for use during pregnancy and lactation (breastfeeding).

Side effects

Depending on the incidence, the following groups of side effects are distinguished: very rare - less than 0.01%, rare - more than 0.01% and less than 0.1%, infrequent - more than 0.1% and less than 1%, frequent - more than 1% and less than 10%, very frequent - more than 10%.
On the part of the nervous system: very frequent - drowsiness, sedation; frequent dizziness, weakness, fatigue, confusion, gait disturbance, insomnia, euphoria, depression, asthenia, ataxia, tremor, hallucinations, nightmares, nystagmus, dry mouth; rare - paresthesia, dysarthria.
Since the cardiovascular system: frequent - reduction of cardiac output, arterial hypotension.
On the part of the gastrointestinal tract: very frequent - nausea; frequent - vomiting, constipation, diarrhea, dyspeptic symptoms; rare - abdominal pain, dysgeusia, abnormal liver function.
On the part of the respiratory system: frequent - respiratory depression.
On the part of the musculoskeletal system: frequent - myalgia.
On the part of the senses: frequent - accommodation paresis, visual disturbances.
From the skin and subcutaneous tissue: frequent - hyperhidrosis, rash.
On the part of the kidneys and urinary system: frequent - polyuria, enuresis, dysuria; rare - urinary retention.
Reproductive system: rare - erectile dysfunction.
General disorders: very rare - hypothermia.
In isolated cases, an increase in spasticity was observed, which was regarded as a paradoxical reaction to the drug.

Terms and conditions of storage

List B.The drug should be stored in a dry, dark place and out of reach of children at a temperature not exceeding 25 ° C. Shelf life - 3 years.

Indications

Increased muscle tone with:
- multiple sclerosis;
- diseases of the spinal cord (tumor, syringomyelia, motor neuron disease, trauma, myelitis);
- cerebrovascular diseases;
- cerebral palsy;
- meningitis;
- traumatic brain injuries.

Contraindications

- psychosis;
- Parkinson's disease;
- epilepsy;
- convulsions (including anamnesis);
- gastric ulcer and duodenal ulcer;
- Lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
- pregnancy;
- lactation (breastfeeding);
- hypersensitivity to baclofen.
With caution, the drug is prescribed for cerebrovascular insufficiency, cerebral atherosclerosis, chronic renal failure, in elderly patients, children under 3 years of age.

special instructions

Side effects often have a transient nature, they should be distinguished from the symptoms of the disease about which the treatment is carried out: with concomitant epilepsy, treatment is carried out without discontinuation of anti-epileptic drugs.
In patients with diseases of the liver and diabetes mellitus, it is necessary to periodically monitor the activity of hepatic transaminases and alkaline phosphatase, as well as blood glucose.

Influence on ability to drive motor transport and control mechanisms

Patients taking Baklosan, should refrain from potentially hazardous activities associated with the need for increased attention and quick psychomotor reactions.

When kidney damage

Contraindicated in chronic renal failure.

With abnormal liver function

In patients with liver disease, it is necessary to periodically monitor the activity of hepatic transaminases.

Use in old age

With caution, prescribe the drug to elderly patients.

Use in childhood

Be wary appoint the drug to children under the age of 12 years.

Pharmacy sales terms

The drug is available on prescription.

It is a pharmaceutical drug. Use only as directed by your doctor.