Pentalgin ICN №12 pills

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Pentalgin ICN №12 pills

Pharmaceutical action

Combined medication, the action of which is due to the effects of its constituent components. It has analgesic, antipyretic, anti-inflammatory and some sedative effects.
Metamizol sodium and paracetamol have an analgesic, antipyretic and anti-inflammatory effect due to inhibition of COX and inhibition of prostaglandin synthesis.
Codeine is an agonist of opioid receptors, has a central antitussive effect (by suppressing the excitability of the cough and respiratory centers), as well as some central analgesic effect.
Phenobarbital has a sedative effect, potentiates the central analgesic effect.
Caffeine increases cerebral blood flow.
Codeine and caffeine increase the analgesic effect of the analgesics that make up the drug.

Contraindications

- pulmonary insufficiency
- an attack of bronchial asthma
- respiratory failure due to depression of the respiratory center
- severe liver dysfunction
- expressed renal dysfunction
- child age up to 12 years
Increased sensitivity to the components of the drug.

special instructions

Side effects:
From the digestive system: nausea, vomiting, erosive and ulcerative lesions of the gastrointestinal tract.
From the side of the central nervous system: drowsiness, lethargy, decreased ability to concentrate.
From the hemopoietic system: granulocytopenia, agranulocytosis.
Allergic reactions: skin rash.
Pregnancy:
When using Pentalgin-ICN during pregnancy, it should be borne in mind that sodium included in the drug metamizole may reduce the contractile activity of the myometrium (due to suppression of prostaglandin synthesis), and codeine may cause respiratory failure in the newborn.
If necessary, use Pentalgin-ICN during lactation should decide on the termination of breastfeeding.
Interaction:
With the simultaneous use of Pentalgin-ICN with non-opioid analgesics, toxic effects may be enhanced.
With the simultaneous use of sedatives and tranquilizers, there is an increase in the analgesic effect of Pentalgin-ICN.
With the simultaneous use of Pentalgin-ICN and tricyclic antidepressants, hormonal contraceptives for oral administration, allopurinol there is an increase in the toxicity of metamizole sodium (which is part of the drug).
With the simultaneous use of Pentalgin-ICN and barbiturates, phenylbutazone and other inducers of microsomal liver enzymes, a weakening of the action of metamizole sodium (which is part of the preparation) is noted.
With the simultaneous use of Pentalgin-ICN with cyclosporine, there is a decrease in the level of the latter in the blood due to its interaction with metamizole sodium, which is part of the drug.
With the simultaneous use of Pentalgin-ICN with ethanol, codeine, which is part of the preparation, enhances the effect of ethanol.

Precautionary measures

List B. The drug should be stored in a dry, dark place. Shelf life - 2 years.
Pharmacy sales terms
The drug is approved for use as a means of OTC.


It is a pharmaceutical drug. Use only as directed by your doctor.

Mode of application

The drug is prescribed inside 1 tab. 1-3 times / day The duration of application depends on the effect achieved and, as a rule, does not exceed 5 days.