Zyvox 600mg №10 pills


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Zyvox 600mg №10 pills

Pharmaceutical action

Antibacterial drug belongs to the class of oxazolidinones. The mechanism of drug action is due to inhibition of protein synthesis in bacteria. Linezolid, due to its binding to bacterial ribosomes, prevents the formation of the functional initiating complex 70S, which is a component of the translation process during protein synthesis.
A drugactive against aerobic gram-positive bacteria: Corynebacterium jeikeium, Enterococcus faecalis (including glycopeptide-resistant strains), Clickel-Clickschuli, C-necroschrocchylchaeceans, Including glycopeptide-resistant strains, Enterococcus casseliflavus, Enterococcus gallinarum, Listeria monocytogenes, Staphylococcus aureus (including methycyl clucylumus, Listeria monocytogenes, Staphylococcus aureus (including methycyl cilium) glycopeptides), Staphylococcus epidermidis (including methicillin-resistant strains), Staphylococcus haemolyticus, Staphylococcus lugdunensis, Streptococcus agalactiae, Streptococcus intermedius, Streptococcus pneumoniae (including strains with interim mobility patterns, I’m not a hint, I have to be in a simple way, I have to make myself and I have to make myself lag a bit of a hint, I’m going to have a hint of visibility, I’m going to have to do it, I’m going to be (Streptococcus groups C and G), Streptococcus pyrogenes, Streptococcus viridansaerobic gram-negative bacteria: Pasteurella canis, Pasteurella multocidaanaerobic gram-positive bacteria: Clostridium perfringens, Peptostreptococcus spp. (including Peptostreptococcus anaerobius)anaerobic gram-negative bacteria: Bacteroides fragilis, Prevotella spp. Chlamydia pneumoniae.
To drugmoderately sensitive Legionella spp., Moraxella catarrhalis, Mycoplasma spp.
To drugare resistant Haemophilus influenzae, Neisseria spp., Enterobacteriaceae, Pseudomonas spp.
There was no cross-resistance between Zyvox and aminoglycosides, beta-lactam antibiotics, folic acid antagonists, glycopeptides, linkosamides, quinolones, rifamycins, streptogramines, tetracyclines, chloramphenicol.
Resistance to Zyvox develops slowly by multistage mutation of 23S ribosomal RNA and occurs at a frequency of less than 1x10-9-1x10-11.
The in vitro post-antibiotic effect of Zyvox is about 2 hours for Staphylococcus aureus, in vivo (in experimental animal studies) - 3.6 hours and 3.9 hours for Staphylococcus aureus and Staphylococcus pneumoniae, respectively.


- hypersensitivity to linezolid and other components of the drug.

special instructions

Side effects:

From the digestive system: at least 1% - taste perversion, nausea, vomiting, diarrhea, abdominal pain (including spastic), flatulence, changes in total bilirubin, ALT, AST, SchP.
From the hemopoietic system: reversible anemia, thrombocytopenia, leukopenia, pancytopenia.
Other: headache, candidiasis is very rare - cases of peripheral neuropathy and optic nerve neuropathy when used for more than 28 days (the relationship between the use of Zyvox and the development of neuropathy has not been proven).
Adverse reactions do not depend on the dose and, as a rule, do not require cessation of treatment.

Adequate and strictly controlled studies of the safety of the drug Zyvoks during pregnancy was not conducted. The use of Zyvox during pregnancy is possible only in cases where the intended benefit of therapy for the mother outweighs the potential risk.
It is not known whether linezolid is excreted in breast milk of lactating women, therefore special care should be taken when prescribing the drug to the mother during the breastfeeding period.

Linezolid is a weak, reversible, non-selective inhibitor of MAO, so in some patients, Zyvox can cause a moderate reversible increase in the pressor action of pseudoephedrine hydrochloride and phenylpropanolamine hydrochloride. Taking this into account, with simultaneous use of Zyvox with adrenergic drugs, it is recommended to reduce the initial doses of the latter and to further select the dose by titration.
Pharmacokinetic interaction
With simultaneous administration of Zyvox with aztreonam and gentamicin, no changes in the pharmacokinetics of linezolid were observed.

It is a pharmaceutical drug. Use only as directed by your doctor.

Mode of application

For adults the drug is prescribed 2 times / day.