Zyvox solution for infusions 2mg / ml 100ml No. 10 packs

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Zyvox solution for infusion 2mg / ml 100ml №10 packages

Release form

Infusion Solution

Composition

1 ml of solution contains linezolid 2 mg.

Packaging

10 infusion disposable packs of 100 ml.

pharmachologic effect

Antimicrobial drug, belongs to the class of oxazolidinones. The mechanism of action of Zyvox is due to selective inhibition of protein synthesis in bacteria. By linking with bacterial ribosomes, linezolid prevents the formation of a functional 70S initiator complex, which is a component of the translation process during protein synthesis.

Indications

Treatment of infectious and inflammatory diseases caused by anaerobic and aerobic gram-positive microorganisms sensitive to the drug (including infections accompanied by bacteremia):
community-acquired pneumonia;
hospital pneumonia;
skin and soft tissue infections;
infections caused by Enterococcus spp. (including vancomycin resistant strains of Enterococcus faecalis and Enterococcus faecium).
Infections caused by gram-negative microorganisms, confirmed or suspected (as part of combination therapy).

Contraindications

Hypersensitivity to linezolid and / or other components of Zyvox.

Use during pregnancy and lactation

Adequate and strictly controlled studies of the safety of the drug Zyvoks during pregnancy was not conducted. The use of Zyvox during pregnancy is possible only in cases where the intended benefit of therapy for the mother outweighs the potential risk. It is not known whether linezolid is excreted in breast milk, therefore, breastfeeding should be discontinued when prescribing the drug to the mother during lactation.

Dosage and administration

Solution for infusion should be administered in / for 30-120 minutes. Appointed in the recommended single dose 2 times a day. The recommended dose of Zivox 600 mg.

Side effects

On the part of the digestive system: at least 1% - taste perversion, nausea, vomiting, diarrhea, abdominal pain (including spastic), flatulence, changes in total bilirubin, ALT, AST, ALP.
From the hemopoietic system: reversible anemia, thrombocytopenia, leukopenia, pancytopenia.
Others: headache, candidiasis; very rarely, cases of peripheral neuropathy and optic nerve neuropathy when used for more than 28 days (the relationship between the use of Zyvox and the development of neuropathy has not been proven).
Adverse reactions do not depend on the dose and, as a rule, do not require cessation of treatment.

special instructions

When diarrhea develops in patients taking Zyvox, the risk of developing pseudomembranous colitis of varying severity should be considered.

Drug interaction

Linezolid is a weak, reversible, non-selective inhibitor of MAO, so in some patients, Zyvox can cause a moderate reversible increase in the pressor action of pseudoephedrine hydrochloride and phenylpropanolamine hydrochloride. Taking this into account, with simultaneous use of Zyvox with adrenergic drugs, it is recommended to reduce the initial doses of the latter and to further select the dose by titration.
Pharmacokinetic interaction
With simultaneous administration of Zyvox with aztreonam and gentamicin, no changes in the pharmacokinetics of linezolid were observed.

Storage conditions

The drug should be stored in a dry, dark place at temperatures not above 20 ° C.

Shelf life

3 years.

It is a pharmaceutical drug. Use only as directed by your doctor.